PREDICTORS AND CONSEQUENCES OF ALLERGIES THAT IMPACT ON CHILDREN GETTING A HEALTHY START TO LIFE: A PROSPECTIVE STUDY
Grant number: 454856 | Funding period: 2007 - 2012
Allergic diseases prevent Australian children getting a healthy start to life by causing long term illnesses. This group of diseases includes asthma, hay fever, eczema and food allergies. Half of all Australian children are born into families with a history of these conditions and these children are at increased risk. Some of these children develop allergies while the others do not. It is also known that allergic conditions change over time, but we have no information on causes of these changes. For example some infants with eczema continue to have eczema or develop hay fever and asthma, while others do not. The aim of this study is to determine what factors cause allergies and what factors ..View full description
Related publications (14)
Early life acetaminophen exposure, glutathione S-transferase genes, and development of adolescent asthma in a high-risk birth cohort
Xin Dai, Shyamali C Dharmage, Michael J Abramson, Bircan Erbas, Catherine M Bennett, Cecilie Svanes, Jennie Hui, Christine Axelrad, Adrian J Lowe, Caroline J Lodge
BACKGROUND: Although the impact of early life acetaminophen on asthma risk is still not clear, potential interactions with glutath..
Is self-reported history of eczema and hay fever a valid measure of atopy in those who report current asthma?
Kathrine Pape, Vivi Schlunssen, Caroline Jane Lodge, Jennifer L Perret, E Haydn Walters, Dinh Bui, Bircan Erbas, Cecilie Svanes, Garun S Hamilton, Paul S Thomas, Karin S Hougaard, Michael J Abramson, Shyamali C Dharmage, Adrian J Lowe
Transient childhood wheeze is associated with less atopy in adolescence
Caroline Jane Lodge, Adrian John Lowe, Michael John Abramson, Cecilie Svanes, Sophie G Zaloumis, Paul S Thomas, Shyamali Chandrika Dharmage
BACKGROUND: The relationships between childhood wheeze phenotypes and subsequent allergic conditions other than asthma, including ..
Early-Life Exposure to Oral Antibiotics and Lung Function Into Early Adulthood
Karoliny dos Santos, Caroline J Lodge, Michael J Abramson, Bircan Erbas, Catherine M Bennett, Jennie Hui, Shyamali C Dharmage, Adrian J Lowe
BACKGROUND: Although there is ongoing debate regarding the impact of early postnatal exposure to antibiotics on the development of..
Outdoor fungal spores and acute respiratory effects in vulnerable individuals
Rachel Tham, Bircan Erbas, Shyamali C Dharmage, Mimi LK Tang, Fahad Aldakheel, Caroline J Lodge, Paul S Thomas, Philip E Taylor, Michael J Abramson, Adrian J Lowe
BACKGROUND: Many outdoor fungal spores are ubiquitous, respirable and possibly allergenic. They may contribute to asthma symptoms;..
Pollen exposure at birth and adolescent lung function, and modification by residential greenness
Katrina A Lambert, Caroline Lodge, Adrian J Lowe, Luke A Prendergast, Paul S Thomas, Catherine M Bennett, Michael J Abramson, Shyamali C Dharmage, Bircan Erbas
BACKGROUND: Exposure to high levels of pollen in infancy is a risk factor for allergic respiratory diseases in later childhood, bu..
The Role of Early Life Food Sensitization in Adolescent Lung Function: Results from 2 Birth Cohort Studies
Shatha Alduraywish, Agnes Luzak, Caroline Lodge, Fahad Aldakheel, Bircan Erbas, Katrina Allen, Melanie Matheson, Lyle Gurrin, Joachim Heinrich, Irina Lehmann, Andrea von Berg, Marie Standl, Michael Abramson, Holger Schulz, Adrian Lowe, Shyamali C Dharmage
BACKGROUND: It is unclear whether early life food sensitization (as opposed to aeroallergen sensitization) is associated with subs..
Early-life exposure to sibling modifies the relationship between CD14 polymorphisms and allergic sensitization
Melisa YZ Lau, Shyamali C Dharmage, John A Burgess, Aung K Win, Adrian J Lowe, Caroline J Lodge, Jennifer Perret, Jennie Hui, Paul S Thomas, Graham Giles, Bruce R Thompson, Michael J Abramson, E Haydn Walters, Melanie C Matheson, Katrina J Allen, Geza Benke, James G Dowty, Bircan Erbas, Iain H Feather, Peter A Frith
BACKGROUND: Markers of microbial exposure are thought to be associated with risk of allergic sensitization; however, the associati..
NOx in exhaled breath condensate is related to allergic sensitization in young and middle-aged adults
Fahad M Aldakheel, Jane E Bourke, Paul S Thomas, Melanie C Matheson, Michael J Abramson, Garun S Hamilton, Caroline J Lodge, BruceR Thompson, E Haydn Walters, Katrina J Allen, Bircan Erbas, Jennifer L Perret, Shyamali C Dharmage, Adrian J Lowe
BACKGROUND: Asthma and allergic diseases are heterogeneous. Measurement of biomarkers in exhaled breath condensate (EBC) may help ..
Environmental grass pollen levels in utero and at birth and cord blood IgE: Analysis of three birth cohorts
Nugroho Harry Susanto, Ann-Marie Malby Schoos, Marie Standl, Adrian J Lowe, Shyamali C Dharmage, Cecilie Svanes, Agus Salim, Andrea von Berg, Irina Lehmann, Morten Arendt Rasmussen, Matthias Werchan, Karl-Christian Bergmann, Caroline Lodge, Michael J Abramson, Joachim Heinrich, Hans Bisgaard, Bircan Erbas
BACKGROUND: Early life factors are associated with allergic respiratory diseases, but the role of high grass pollen concentrations..
Breast milk polyunsaturated fatty acids: associations with adolescent allergic disease and lung function
NT Waidyatillake, R Stoney, F Thien, CJ Lodge, JA Simpson, KJ Allen, MJ Abramson, B Erbas, C Svanes, SC Dharmage, AJ Lowe
BACKGROUND: It has been hypothesized that n-3 PUFA in breast milk may assist immune and lung development. There are very limited d..
Genetic variation at the Th2 immune gene IL13 is associated with IgE-mediated paediatric food allergy
SE Ashley, H-TT Tan, R Peters, KJ Allen, P Vuillermin, SC Dharmage, MLK Tang, J Koplin, A Lowe, A-L Ponsonby, J Molloy, MC Matheson, R Saffery, JA Ellis, D Martino
BACKGROUND: Food allergies pose a considerable world-wide public health burden with incidence as high as one in ten in 12-month-ol..
Age at onset and persistence of eczema are related to subsequent risk of asthma and hay fever from birth to 18 years of age
Adrian J Lowe, Bianca Angelica, John Su, Caroline J Lodge, David J Hill, Bircan Erbas, Catherine M Bennett, Lyle C Gurrin, Christine Axelrad, Michael J Abramson, Katrina J Allen, Shyamali C Dharmage
BACKGROUND: Few studies have simultaneously addressed the importance of age of onset and persistence of eczema for the subsequent ..
Cohort Profile: Melbourne Atopy Cohort study (MACS)
Adrian J Lowe, Caroline J Lodge, Katrina J Allen, Michael J Abramson, Melanie C Matheson, Paul S Thomas, Christopher A Barton, Catherine M Bennett, Bircan Erbas, Cecilie Svanes, Mathias Wjst, Francisco Gomez Real, Jennifer L Perret, Melissa A Russell, Melissa C Southey, John L Hopper, Lyle C Gurrin, Christine J Axelrad, David J Hill, Shyamali C Dharmage