NEW DRUGS TO REDUCE THE SIDE-EFFECTS OF CANCER RADIOTHERAPY
Grant number: 454674
The proposed project is part of a research programme aimed at developing a new drug to reduce the side effects of cancer radiotherapy. These side effects result from the radiation damage to normal tissues close to the tumour. Since in many instances the normal tissues at risk are accessible to topical application (eg. skin in breast cancer patients, rectal mucosa in prostate cancer patients, oral mucosa in all patients being treated for tumours in the head and neck region) the concept is very simple. A drug which makes cells less sensitive to X-rays (these drugs are called radioprotectors) is simply applied topically to the normal tissues at risk. For this purpose, we have developed a new ra..View full description
Related publications (1)
Protection by methylproamine of irradiated human keratinocytes correlates with reduction of DNA damage
Pavel N Lobachevsky, Raja S Vasireddy, Sam Broadhurst, Carl N Sprung, Tom C Karagiannis, Andrea J Smith, Ian R Radford, Michael J McKay, Roger F Martin
PURPOSE: The therapeutic ratio for ionising radiation treatment of tumour is a trade-off between normal tissue side-effects and tu..