Building Molrculary Engineered Polymer Nanomaterials

Grant number: FF0776078 | Funding period: 2007 - 2012

Completed

Abstract

The development of new technologies at the interface between nano- and biotechnology promises to revolutionise healthcare and medicine. This research program will involve the design and synthesis of responsive and programmable polymers and their assembly to form next-generation, engineered materials. The nanomaterials prepared are expected to lead to the development of techniques that enable new types of minimally invasive diagnostics and therapeutics as well as smaller devices. The interdisciplinary research program will cement Australia's position as a leading country in nanobiotechnology research and development.

Related publications (30)

Scholarly works icon

Near-Incompressible Faceted Polymer Microcapsules from Metal-Organic Framework Templates

Hirotaka Ejima, Nobuhiro Yanai, James P Best, Melinda Sindoro, Steve Granick, Frank Caruso

2013-10-01

Scholarly works icon

One-Step Assembly of Coordination Complexes for Versatile Film and Particle Engineering

Hirotaka Ejima, Joseph J Richardson, Kang Liang, James P Best, Martin P van Koeverden, Georgina K Such, Jiwei Cui, Frank Caruso

2013-07-12

Scholarly works icon

Templated Assembly of pH-Labile Polymer-Drug Particles for Intracellular Drug Delivery

Jiwei Cui, Yan Yan, Yajun Wang, Frank Caruso

2012-11-21

Scholarly works icon

Biomimetic Liposome- and Polymersome-Based Multicompartmentalized Assemblies

Rona Chandrawati, Frank Caruso

2012-10-02

Scholarly works icon

Immobilization and Intracellular Delivery of an Anticancer Drug Using Mussel-Inspired Polydopamine Capsules

Jiwei Cui, Yan Yan, Georgina K Such, Kang Liang, Christopher J Ochs, Almar Postma, Frank Caruso

2012-08-01

Scholarly works icon

Targeting Cancer Cells: Controlling the Binding and Internalization of Antibody-Functionalized Capsules

Angus PR Johnston, Marloes MJ Kamphuis, Georgina K Such, Andrew M Scott, Edouard C Nice, Joan K Heath, Frank Caruso

2012-08-01

Scholarly works icon

Nanoporous Peptide Particles for Encapsulating and Releasing Neurotrophic Factors in an Animal Model of Neurodegeneration

Justin Tan, Yajun Wang, Xiaopei Yip, Fergal Glynn, Robert K Shepherd, Frank Caruso

2012-07-03

Scholarly works icon

Engineering Particles for Therapeutic Delivery: Prospects and Challenges

Yan Yan, Georgina K Such, Angus PR Johnston, James P Best, Frank Caruso

2012-05-01

Scholarly works icon

Photoinitiated Alkyne-Azide Click and Radical Cross-Linking Reactions for the Patterning of PEG Hydrogels

Rodney T Chen, Silvia Marchesan, Richard A Evans, Katie E Styan, Georgina K Such, Almar Postma, Keith M McLean, Benjamin W Muir, Frank Caruso

2012-03-01

Scholarly works icon

Macromolecule Functionalization of Disulfide-Bonded Polymer Hydrogel Capsules and Cancer Cell Targeting

Olga Shimoni, Almar Postma, Yan Yan, Andrew M Scott, Joan K Heath, Edouard C Nice, Alexander N Zelikin, Frank Caruso

2012-02-01

Scholarly works icon

The Role of Particle Geometry and Mechanics in the Biological Domain

James P Best, Yan Yan, Frank Caruso

2012-01-11

Scholarly works icon

Bio-Click Chemistry: Enzymatic Functionalization of PEGylated Capsules for Targeting Applications

Melissa KM Leung, Christoph E Hagemeyer, Angus PR Johnston, Catalina Gonzales, Marloes MJ Kamphuis, Katie Ardipradja, Georgina K Such, Karlheinz Peter, Frank Caruso

2012-01-01

Scholarly works icon

Cellular Association and Cargo Release of Redox-Responsive Polymer Capsules Mediated by Exofacial Thiols

Yan Yan, Yajun Wang, Joan K Heath, Edouard C Nice, Frank Caruso

2011-09-08

Scholarly works icon

Polymersome-Loaded Capsules for Controlled Release of DNA

Hannah Lomas, Angus PR Johnston, Georgina K Such, Zhiyuan Zhu, Kang Liang, Martin P van Koeverden, Siripong Alongkornchotikul, Frank Caruso

2011-07-18

Scholarly works icon

Dopamine-Mediated Continuous Assembly of Biodegradable Capsules

Christopher J Ochs, Tam Hong, Georgina K Such, Jiwei Cui, Almar Postma, Frank Caruso

2011-07-12

Scholarly works icon

Challenges facing colloidal delivery systems: From synthesis to the clinic

Angus PR Johnston, Georgina K Such, Sher Leen Ng, Frank Caruso

2011-06-01

Scholarly works icon

Toward Therapeutic Delivery with Layer-by-Layer Engineered Particles

Yan Yan, Georgina K Such, Angus PR Johnston, Hannah Lomas, Frank Caruso

2011-06-01

Scholarly works icon

Bypassing Multidrug Resistance in Cancer Cells with Biodegradable Polymer Capsules

Yan Yan, Christopher J Ochs, Georgina K Such, Joan K Heath, Edouard C Nice, Frank Caruso

2010-12-14

Scholarly works icon

Targeting of Cancer Cells Using Click-Functionalized Polymer Capsules

Marloes MJ Kamphuis, Angus PR Johnston, Georgina K Such, Henk H Dam, Richard A Evans, Andrew M Scott, Edouard C Nice, Joan K Heath, Frank Caruso

2010-11-17

Scholarly works icon

Monitoring ion-channel function in real time through quantum decoherence

Liam T Hall, Charles D Hill, Jared H Cole, Brigitte Staedler, Frank Caruso, Paul Mulvaney, Joerg Wrachtrup, Lloyd CL Hollenberg

2010-11-02

Scholarly works icon

Encapsulation of Water-Insoluble Drugs in Polymer Capsules Prepared Using Mesoporous Silica Templates for Intracellular Drug Delivery

Yajun Wang, Yan Yan, Jiwei Cui, Leticia Hosta-Rigau, Joan K Heath, Edouard C Nice, Frank Caruso

2010-10-08

Scholarly works icon

Layer-By-Layer-Assembled Capsules and Films for Therapeutic Delivery

Alisa L Becker, Angus PR Johnston, Frank Caruso

2010-09-06

Scholarly works icon

Uptake and Intracellular Fate of Disulfide-Bonded Polymer Hydrogel Capsules for Doxorubicin Delivery to Colorectal Cancer Cells

Yan Yan, Angus PR Johnston, Sarah J Dodds, Marloes MJ Kamphuis, Charles Ferguson, Robert G Parton, Edouard C Nice, Joan K Heath, Frank Caruso

2010-05-01

Scholarly works icon

Biodegradable Click Capsules with Engineered Drug-Loaded Multilayers

Christopher J Ochs, Georgina K Such, Yan Yan, Martin P van Koeverden, Frank Caruso

2010-03-01

Scholarly works icon

Engineering Advanced Capsosomes: Maximizing the Number of Subcompartments, Cargo Retention, and Temperature-Triggered Reaction

Rona Chandrawati, Leticia Hosta-Rigau, Dirk Vanderstraaten, Shalitha A Lokuliyana, Brigitte Stadler, Fernando Albericio, Frank Caruso

2010-03-01

Scholarly works icon

Capsosomes with Multilayered Subcompartments: Assembly and Loading with Hydrophobic Cargo

Leticia Hosta-Rigau, Brigitte Staedler, Yan Yan, Edouard Collins Nice, Joan K Heath, Fernando Albericio, Frank Caruso

2010-01-08

Scholarly works icon

A Protective Vaccine Delivery System for In Vivo T Cell Stimulation Using Nanoengineered Polymer Hydrogel Capsules

Amy Sexton, Paul G Whitney, Siow-Feng Chong, Alexander N Zelikin, Angus PR Johnston, Robert De Rose, Andrew G Brooks, Frank Caruso, Stephen J Kent

2009-11-01

Scholarly works icon

Degradable, Surfactant-Free, Monodisperse Polymer-Encapsulated Emulsions as Anticancer Drug Carriers

Sri Sivakumar, Vipul Bansal, Christina Cortez, Siow-Feng Chong, Alexander N Zelikin, Frank Caruso

2009-05-11

Scholarly works icon

Templated synthesis of single-component polymer capsules and their application in drug delivery

Yajun Wang, Vipul Bansal, Alexander N Zelikin, Frank Caruso

2008-06-01

Scholarly works icon

Influence of size, surface, cell line, and kinetic properties on the specific binding of A33 antigen-targeted multilayered particles and capsules to colorectal cancer cells

Christina Cortez, Eva Tomaskovic-Crook, Angus PR Johnston, Andrew M Scott, Edouard C Nice, Joan K Heath, Frank Caruso

2007-09-01

Researchers