Physiology and pathology of novel forms of progastrin
Grant number: 509074 | Funding period: 2008 - 2011
Gastrin is a stomach hormone which increases acid secretion and the growth of the stomach and bowel. This growth promoting effect may be involved in a number of cancers especially colon cancer. The different types of gastrins have different effects but we do not know which forms are important and whether all are active. The types and activity of the different gastrins will be investigated using cell lines, animal models and colon cancer patients with the view of establishing new treatments.
Related publications (1)
The C-terminal flanking peptide (CTFP) of progastrin inhibits apoptosis via a PI3-kinase-dependent pathway
Oneel Patel, Kathryn M Marshall, Gianni Bramante, Graham S Baldwin, Arthur Shulkes
Progastrin is processed to a number of peptides including glycine-extended gastrin, amidated gastrin and the C-terminal flanking p..