Peptide neurotransmission in mental health and psychiatric illness

Relaxin-3 receptor (Rxfp3) gene knockout mice display reduced running wheel activity: Implications for role of relaxin-3/RXFP3 signalling in sustained arousal

Ihaia T Hosken, Steven W Sutton, Craig M Smith, Andrew L Gundlach

2015-02-01

Anatomical and pharmacological evidence suggests the neuropeptide, relaxin-3, is the preferred endogenous ligand for the relaxin f..

Central injection of relaxin-3 receptor (RXFP3) antagonist peptides reduces motivated food seeking and consumption in C57BL/6J mice

Craig M Smith, Berenice E Chua, Cary Zhang, Andrew W Walker, Mouna Haidar, David Hawkes, Fazel Shabanpoor, Mohammad Akhter Hossain, John D Wade, K Johan Rosengren, Andrew L Gundlach

2014-07-15

Behavioural arousal in mammals is regulated by various interacting central monoamine- and peptide-neurotransmitter/receptor system..

Relaxin-3 mRNA levels in nucleus incertus correlate with alcohol and sucrose intake in rats

PJ Ryan, EV Krstew, M Sarwar, AL Gundlach, AJ Lawrence

2014-07-01

BACKGROUND: Chronic alcohol intake produces multiple neuroadaptive changes, including up- and down-regulation of neuropeptides and..

Relaxin-3/RXFP3 networks: an emerging target for the treatment of depression and other neuro psychiatric diseases?

Craig M Smith, Andrew W Walker, Ihaia T Hosken, Berenice E Chua, Cary Zhang, Mouna Haidar, Andrew L Gundlach

2014-03-21

Animal and clinical studies of gene-environment interactions have helped elucidate the mechanisms involved in the pathophysiology ..

Relaxin-3/RXFP3 system regulates alcohol-seeking

Philip J Ryan, Hanna E Kastman, Elena V Krstew, K Johan Rosengren, Mohammed Akhter Hossain, Leonid Churilov, John D Wade, Andrew L Gundlach, Andrew J Lawrence

2013-12-17

Relapse and hazardous drinking represent the most difficult clinical problems in treating patients with alcohol use disorders. Usi..

Heterogeneous responses of nucleus incertus neurons to corticotrophin-releasing factor and coherent activity with hippocampal theta rhythm in the rat

Sherie Ma, Anna Blasiak, Francisco E Olucha-Bordonau, Anthony JM Verberne, Andrew L Gundlach

2013-08-15

The nucleus incertus (NI) of the rat hindbrain is a putative node in the ascending control of the septohippocampal system and hipp..

Modulation of feeding by chronic rAAV expression of a relaxin-3 peptide agonist in rat hypothalamus

DE Ganella, GE Callander, S Ma, CR Bye, AL Gundlach, RAD Bathgate

2013-07-01

Relaxin-3 is a neuropeptide that is abundantly expressed by discrete brainstem neuron populations that broadly innervate forebrain..

Modulation of feeding by chronic rAAV expression of a relaxin-3 peptide agonist in rat hypothalamus

DE Ganella, GE Callander, S Ma, CR Bye, AL Gundlach, RAD Bathgate

2013-07-01

Relaxin-3 is a neuropeptide that is abundantly expressed by discrete brainstem neuron populations that broadly innervate forebrain..

Central relaxin-3 receptor (RXFP3) activation decreases anxiety- and depressive-like behaviours in the rat

Philip J Ryan, Elena Buechler, Fazel Shabanpoor, Mohammed Akhter Hossain, John D Wade, Andrew J Lawrence, Andrew L Gundlach

2013-05-01

Relaxin-3 is a recently discovered neuropeptide and the results of earlier anatomical and pharmacological studies suggest it plays..

Relaxin-3 innervation of the intergeniculate leaflet of the rat thalamus - neuronal tract-tracing and in vitro electrophysiological studies

Anna Blasiak, Tomasz Blasiak, Marian H Lewandowski, Mohammed Akhter Hossain, John D Wade, Andrew L Gundlach

2013-04-01

Behavioural state is controlled by a range of neural systems that are sensitive to internal and external stimuli. The relaxin-3 an..

Minimization of Human Relaxin-3 Leading to High-Affinity Analogues with Increased Selectivity for Relaxin-Family Peptide 3 Receptor (RXFP3) over RXFP1

Fazel Shabanpoor, Mohammad Alchter Hossain, Philip J Ryan, Alessia Belgi, Sharon Layfield, Martina Kocan, Suode Zhang, Chrishan S Samuel, Andrew L Gundlach, Ross AD Bathgate, Frances Separovic, John D Wade

2012-02-23

Relaxin-3 is a neuropeptide that is implicated in the regulation of stress responses and memory. The elucidation of its precise ph..

Modulation of hippocampal theta oscillations and spatial memory by relaxin-3 neurons of the nucleus incertus

Sherie Ma, Francisco E Olucha-Bordonau, M Akhter Hossain, Feng Lin, Chester Kuei, Changlu Liu, John D Wade, Steven W Sutton, Angel Nunez, Andrew L Gundlach

2009-11-01

Hippocampal theta rhythm is thought to underlie learning and memory, and it is well established that "pacemaker" neurons in medial..

Structure and Activity in the Relaxin Family of Peptides

Geoffrey W Tregear, Ross AD Bathgate, Mohammed Akhter Hossain, Feng Lin, Suode Zhang, Fazel Shabanpoor, Daniel J Scott, Sherie Ma, Andrew L Gundlach, Chrishan S Samuel, John D Wade

2009-01-01

The availability of improved peptide synthesis procedures, convenient and sensitive assays for receptor binding and activation, to..