Structure-function relationship of human insulin-like peptide 3.
Grant number: 509048 | Funding period: 2008 - 2010
The hormone, insulin-like peptide 3, has recently been shown to act directly on male and female germ cells to cause their maturation. It has considerable promise as a therapeutic agent for the regulation of fertility. Drugs based on the peptide may be used to assist in cases of infertility, and drugs that block its action have great potential as male and female contraceptives. Towards these goals, our project aims to understand how this peptide exerts its unique biological effects.
Related publications (10)
General method for selective labelling of double-chain cysteine-rich peptides with a lanthanide chelate via solid-phase synthesis
Fazel Shabanpoor, Frances Separovic, John D Wade
The use of lanthanides in preference to radioisotopes as probes for various biological assays has gained enormous popularity. The ..
A simple approach for the preparation of mature human relaxin-3
Xiao Luo, Ya-Li Liu, Sharon Layfield, Xiao-Xia Shao, Ross AD Bathgate, John D Wade, Zhan-Yun Guo
Relaxin-3 (also known as INSL7) is the most recently identified member of the insulin-like family. It is predominantly expressed i..
Design and recombinant expression of insulin-like peptide 5 precursors and the preparation of mature human INSL5
Xiao Luo, Ross AD Bathgate, Wei-Jie Zhang, Ya-Li Liu, Xiao-Xia Shao, John D Wade, Zhan-Yun Guo
Insulin-like peptide 5 (INSL5) is a recently identified insulin superfamily member. Although it binds to and activates the G-prote..
Role of the intra-A-chain disulfide bond of insulin-like peptide 3 in binding and activation of its receptor, RXFP2
Suode Zhang, Richard A Hughes, Ross AD Bathgate, Fazel Shabanpoor, M Akhter Hossain, Feng Lin, Bianca van Lierop, Andrea J Robinson, John D Wade
INSL3 is a member of the insulin-IGF-relaxin superfamily and plays a key role in male fetal development and in adult germ cell mat..
Effect of helix-promoting strategies on the biological activity of novel analogues of the B-chain of INSL3
Fazel Shabanpoor, Richard A Hughes, Suode Zhang, Ross AD Bathgate, Sharon Layfield, Mohammed Akhter Hossain, Geoffrey W Tregear, Frances Separovic, John D Wade
Insulin-like 3 (INSL3) is a novel circulating peptide hormone that is produced by testicular Leydig cells and ovarian thecal and l..
Modulation of hippocampal theta oscillations and spatial memory by relaxin-3 neurons of the nucleus incertus
Sherie Ma, Francisco E Olucha-Bordonau, M Akhter Hossain, Feng Lin, Chester Kuei, Changlu Liu, John D Wade, Steven W Sutton, Angel Nunez, Andrew L Gundlach
Hippocampal theta rhythm is thought to underlie learning and memory, and it is well established that "pacemaker" neurons in medial..
Recombinant expression of an insulin-like peptide 3 (INSL3) precursor and its enzymatic conversion to mature human INSL3
Xiao Luo, Ross AD Bathgate, Ya-Li Liu, Xiao-Xia Shao, John D Wade, Zhan-Yun Guo
Insulin-like peptide 3 (INSL3), which is primarily expressed in the Leydig cells of the testes, is a member of the insulin superfa..
Structure and Activity in the Relaxin Family of Peptides
Geoffrey W Tregear, Ross AD Bathgate, Mohammed Akhter Hossain, Feng Lin, Suode Zhang, Fazel Shabanpoor, Daniel J Scott, Sherie Ma, Andrew L Gundlach, Chrishan S Samuel, John D Wade
The availability of improved peptide synthesis procedures, convenient and sensitive assays for receptor binding and activation, to..