The Role of the Innate Immune System in Stomach Cancer

Grant number: 509165 | Funding period: 2008 - 2010

Completed

Abstract

Stomach cancer has a high mortality rate and a poor prognosis. Stomach cancer is one of the few cancers in which the causative pathogen had been demonstrated and eradication of Helicobacter pylori will eliminate the risk of developing cancer but the point at which tumour initiation is irreversible is unknown. Eradication of H. pylori is not always simple or effective. So investigation into initiation events in stomach cancer and development of more sophisticated treatments is warranted.

Related publications (2)

Altered gp130 signalling ameliorates experimental colitis via myeloid cell-specific STAT3 activation and myeloid-derived suppressor cells

J Däbritz, LM Judd, HV Chalinor, TR Menheniott, AS Giraud

2016-02-05

STAT3 regulates the expansion of myeloid-derived suppressor cells (MDSCs) during inflammation, infection and cancer. Hyperactivati..

Inhibition of the JAK2/STAT3 pathway reduces gastric cancer growth in vitro and in vivo

LM Judd, TR Menheniott, H Ling, CB Jackson, M Howlett, A Kalantzis, W Priebe, AS Giraud

2014-05-07

Signal Transducer and Activator of Transcription-3 (STAT3) is constitutively activated in many cancers where it promotes growth, i..

University of Melbourne Researchers

Louise M Judd