PAR-1 is a key regulator of inflammation induced by the human pathogen, Helicobacter pylori
Grant number: 508963 | Funding period: 2008 - 2010
Helicobacter pylori infections cause chronic gastritis which in some people results in stomach cancer or ulcers. We have identified a novel host factor, PAR-1, important for preventing this inflammation. We will use mice to identify how this molecule protects against gastritis and samples from patients to examine its importance in human disease. This will help explain why these diseases develop in some people but not others and perhaps allow identification of those at risk of developing disease.