Cardiac muscle tissue engineering
Grant number: 509271 | Funding period: 2008 - 2011
Heart failure is very costly in the Australian medical system with few effective treatments. We recently developed a new method for generating heart tissue which has potential for a surgical heart failure treatment. We plan now to explore new sources for donor cells from the patients own stem cells, to examine how to best collect the cells during handling and determine whether these methods can provide functional cardiac grafts to improve heart function.
Related publications (11)
Trichostatin A Enhances Differentiation of Human Induced Pluripotent Stem Cells to Cardiogenic Cells for Cardiac Tissue Engineering
Shiang Y Lim, Priyadharshini Sivakumaran, Duncan E Crombie, Gregory J Dusting, Alice Pebay, Rodney J Dilley
Human induced pluripotent stem (iPS) cells are a promising source of autologous cardiomyocytes to repair and regenerate myocardium..
Adipose-Derived Stem Cells Promote Angiogenesis and Tissue Formation for In Vivo Tissue Engineering
Ken Matsuda, Katrina J Falkenberg, Alan A Woods, Yu Suk Choi, Wayne A Morrison, Rodney J Dilley
Adult mesenchymal stem cells secrete a variety of angiogenic cytokines and growth factors, so we proposed that these paracrine mec..
Hypoxic Conditioning Enhances the Angiogenic Paracrine Activity of Human Adipose-Derived Stem Cells
Sarah T Hsiao, Zerina Lokmic, Hitesh Peshavariya, Keren M Abberton, Gregory J Dusting, Shiang Y Lim, Rodney J Dilley
Human adipose-derived stem cells (ASCs) secrete cytokines and growth factors that can be harnessed in a paracrine fashion for prom..
Ischemic Preconditioning Promotes Intrinsic Vascularization and Enhances Survival of Implanted Cells in an In Vivo Tissue Engineering Model
Shiang Y Lim, Sarah T Hsiao, Zerina Lokmic, Priyadharshini Sivakumaran, Gregory J Dusting, Rodney J Dilley
Ischemic preconditioning (IPC) is a potent and effective means of protecting cells against ischemic injury. The protection has bee..
Transplantation of Engineered Cardiac Muscle Flaps in Syngeneic Rats
Richard Tee, Wayne A Morrison, Gregory J Dusting, Guei-Sheung Liu, Yu Suk Choi, Sarah Tzu-Feng Hsiao, Rodney J Dilley
Cardiac tissue engineering offers the prospect of a novel treatment for acquired or congenital heart defects. Previously, our stud..
Comparative Analysis of Paracrine Factor Expression in Human Adult Mesenchymal Stem Cells Derived from Bone Marrow, Adipose, and Dermal Tissue
Sarah Tzu-Feng Hsiao, Azar Asgari, Zerina Lokmic, Rodney Sinclair, Gregory James Dusting, Shiang Yong Lim, Rodney James Dilley
Human adult mesenchymal stem cells (MSCs) support the engineering of functional tissue constructs by secreting angiogenic and cyto..
Hypoxic Preconditioning Enhances Survival of Human Adipose-Derived Stem Cells and Conditions Endothelial Cells In Vitro
Samantha Licy Stubbs, Sarah Tzu-Feng Hsiao, Hitesh Mahendrabhai Peshavariya, Shiang Yong Lim, Gregory James Dusting, Rodney James Dilley
To grow more robust cardiac tissue for implantation in vivo, strategies to improve survival of implanted stem cells are required. ..
Differentiation of human adipose-derived stem cells into beating cardiomyocytes
Yu Suk Choi, Gregory J Dusting, Samantha Stubbs, Sandeep Arunothayaraj, Xiao Lian Han, Philippe Collas, Wayne A Morrison, Rodney J Dilley
Human adipose-derived stem cells (ASCs) may differentiate into cardiomyocytes and this provides a source of donor cells for tissue..