Stem Cells in a Human Pregnancy Disorder

Grant number: 509178 | Funding period: 2008 - 2010

Completed

Abstract

The placenta is a rich source of stem cells. We have discovered that stem cells from placentae affected by fetal growth restriction (FGR), a clinically significant pregnancy disorder, are morphologically and functionally different to normal placental stem cells. We predict that abnormal stem cells contribute to FGR. We will carry out gene expression and functional studies to further characterise the abnormal stem cells. The work may lead to new types of treatments for FGR in future.

Related publications (11)

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Phenotypic and Functional Characterization of Mesenchymal Stem/Multipotent Stromal Cells from Decidua Parietalis of Human Term Placenta

MH Abumaree, FM Abomaray, NA Alshehri, A Almutairi, AS Alaskar, B Kalionis, MA Al Jumah

2016-09-01

Mesenchymal stem/multipotent stromal cells (MSCs) from the human placenta show stem cell-like properties useful for regenerative m..

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Establishment and characterization of fetal and maternal mesenchymal stem/stromal cell lines from the human term placenta

SQ Qin, GD Kusuma, B Al-Sowayan, RA Pace, S Isenmann, MD Pertile, S Gronthos, MH Abumaree, SP Brennecke, B Kalionis

2016-03-01

Introduction Human placental mesenchymal stem/stromal cells (MSC) are an attractive source of MSC with great therapeutic potential..

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Phenotypic and Functional Characterization of Mesenchymal Stem/Multipotent Stromal Cells from Decidua Basalis of Human Term Placenta

FM Abomaray, MA Al Jumah, KO Alsaad, D Jawdat, A Al Khaldi, AS Alaskar, S Al Harthy, AM Al Subayyil, T Khatlani, AO Alawad, A Alkushi, B Kalionis, MH Abumaree

2016-01-01

Mesenchymal stem cell (MSC) therapies for the treatment of diseases associated with inflammation and oxidative stress employ prima..

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Human Chorionic Villous Mesenchymal Stem Cells Modify the Functions of Human Dendritic Cells, and Induce an Anti-Inflammatory Phenotype in CD1 Dendritic Cells

FM Abomaray, MA Al Jumah, B Kalionis, AS AlAskar, S Al Harthy, D Jawdat, A Al Khaldi, A Alkushi, BA Knawy, MH Abumaree

2015-06-04

Background: Mesenchymal stem cells derived from the chorionic villi of human term placenta (pMSCs) have drawn considerable interes..

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A novel combination of homeobox genes is expressed in mesenchymal chorionic stem/stromal cells in first trimester and term pregnancies

H Liu, P Murthi, S Qin, GD Kusuma, AJ Borg, M Knöfler, P Haslinger, U Manuelpillai, MD Pertile, M Abumaree, B Kalionis

2014-11-12

Human chorionic mesenchymal stem/stromal cells (CMSCs) derived fromthe placenta are similar to adult tissue-derived MSCs. The aim ..

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Hepatocyte-like cells derived from human amniotic epithelial cells can be encapsulated without loss of viability or function in vitro

V Vaghjiani, V Vaithilingam, I Saraswati, A Sali, P Murthi, B Kalionis, BE Tuch, U Manuelpillai

2014-04-15

Placenta derived human amniotic epithelial cells (hAEC) are an attractive source of stem cells for the generation of hepatocyte-li..

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Human Placental Mesenchymal Stem Cells (pMSCs) Play a Role as Immune Suppressive Cells by Shifting Macrophage Differentiation from Inflammatory M1 to Anti-inflammatory M2 Macrophages

MH Abumaree, MA Al Jumah, B Kalionis, D Jawdat, A Al Khaldi, FM Abomaray, AS Fatani, LW Chamley, BA Knawy

2013-10-01

Background: Mesenchymal stem cells (MSCs) have a therapeutic potential in tissue repair because of capacity for multipotent differ..

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Phenotypic and Functional Characterization of Mesenchymal Stem Cells from Chorionic Villi of Human Term Placenta

MH Abumaree, MA Al Jumah, B Kalionis, D Jawdat, A Al Khaldi, AA AlTalabani, BA Knawy

2013-02-01

Background: Bone marrow derived mesenchymal stem cells (BM-MSCs) are used extensively in transplantation but their use is associat..

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Decidua parietalis-derived mesenchymal stromal cells reside in a vascular niche within the choriodecidua

NM Castrechini, P Murthi, S Qin, GD Kusuma, L Wilton, M Abumaree, S Gronthos, A Zannettino, NM Gude, SP Brennecke, B Kalionis

2012-12-01

Mesenchymal stromal cells (MSCs) from gestational tissues represent promising cell populations with stem cell-like properties for ..

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Immunosuppressive Properties of Mesenchymal Stem Cells

M Abumaree, M Al Jumah, RA Pace, B Kalionis

2012-06-01

Mesenchymal stem cells (MSC) can be isolated from different adult tissues including bone marrow, adipose tissue, cord blood and pl..

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Mesenchymal stem cells in human placental chorionic villi reside in a vascular Niche

NM Castrechini, P Murthi, NM Gude, JJHM Erwich, S Gronthos, A Zannettino, SP Brennecke, B Kalionis

2010-03-01

The chorionic villi of human term placentae are a rich source of mesenchymal stem cells (PMSCs). The stem cell "niche" within the ..

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