STEM CELLS IN A HUMAN PREGNANCY DISORDER
Grant number: 509178 | Funding period: 2008 - 2010
The placenta is a rich source of stem cells. We have discovered that stem cells from placentae affected by fetal growth restriction (FGR), a clinically significant pregnancy disorder, are morphologically and functionally different to normal placental stem cells. We predict that abnormal stem cells contribute to FGR. We will carry out gene expression and functional studies to further characterise the abnormal stem cells. The work may lead to new types of treatments for FGR in future.
Related publications (9)
Establishment and characterization of fetal and maternal mesenchymal stem/stromal cell lines from the human term placenta
Sharon Q Qin, Gina D Kusuma, Batla Al-Sowayan, Rishika A Pace, Sandra Isenmann, Mark D Pertile, Stan Gronthos, Mohamed H Abumaree, Shaun P Brennecke, Bill Kalionis
INTRODUCTION: Human placental mesenchymal stem/stromal cells (MSC) are an attractive source of MSC with great therapeutic potentia..
Phenotypic and Functional Characterization of Mesenchymal Stem/Multipotent Stromal Cells from Decidua Basalis of Human Term Placenta
FM Abomaray, MA Al Jumah, KO Alsaad, D Jawdat, A Al Khaldi, AS AlAskar, S Al Harthy, AM Al Subayyil, T Khatlani, AO Alawad, A Alkushi, B Kalionis, MH Abumaree
Mesenchymal stem cell (MSC) therapies for the treatment of diseases associated with inflammation and oxidative stress employ prima..
A Novel Combination of Homeobox Genes Is Expressed in Mesenchymal Chorionic Stem/Stromal Cells in First Trimester and Term Pregnancies
Haiying Liu, Padma Murthi, Sharon Qin, Gina D Kusuma, Anthony J Borg, Martin Knoefler, Peter Haslinger, Ursula Manuelpillai, Mark D Pertile, Mohamed Abumaree, Bill Kalionis
Human chorionic mesenchymal stem/stromal cells (CMSCs) derived from the placenta are similar to adult tissue-derived MSCs. The aim..
Hepatocyte-Like Cells Derived from Human Amniotic Epithelial Cells Can Be Encapsulated Without Loss of Viability or Function In Vitro
Vijesh Vaghjiani, Vijayaganapathy Vaithilingam, Indah Saraswati, Adnan Sali, Padma Murthi, Bill Kalionis, Bernard E Tuch, Ursula Manuelpillai
Placenta derived human amniotic epithelial cells (hAEC) are an attractive source of stem cells for the generation of hepatocyte-li..
Human Placental Mesenchymal Stem Cells (pMSCs) Play a Role as Immune Suppressive Cells by Shifting Macrophage Differentiation from Inflammatory M1 to Anti-inflammatory M2 Macrophages
MH Abumaree, MA Al Jumah, B Kalionis, D Jawdat, A Al Khaldi, FM Abomaray, AS Fatani, LW Chamley, BA Knawy
BACKGROUND: Mesenchymal stem cells (MSCs) have a therapeutic potential in tissue repair because of capacity for multipotent differ..
Phenotypic and Functional Characterization of Mesenchymal Stem Cells from Chorionic Villi of Human Term Placenta
MH Abumaree, MA Al Jumah, B Kalionis, D Jawdat, A Al Khaldi, AA AlTalabani, BA Knawy
BACKGROUND: Bone marrow derived mesenchymal stem cells (BM-MSCs) are used extensively in transplantation but their use is associat..
Decidua Parietalis-Derived Mesenchymal Stromal Cells Reside in a Vascular Niche Within the Choriodecidua
NM Castrechini, P Murthi, S Qin, GD Kusuma, L Wilton, M Abumaree, S Gronthos, A Zannettino, NM Gude, SP Brennecke, B Kalionis
Mesenchymal stromal cells (MSCs) from gestational tissues represent promising cell populations with stem cell-like properties for ..
Mesenchymal stem cells in human placental chorionic villi reside in a vascular Niche
NM Castrechini, P Murthi, NM Gude, JJHM Erwich, S Gronthos, A Zannettino, SR Brennecke, B Kalionis
The chorionic villi of human term placentae are a rich source of mesenchymal stem cells (PMSCs). The stem cell "niche" within the ..