STEM CELLS IN A HUMAN PREGNANCY DISORDER
Grant number: 509178 | Funding period: 2008 - 2010
The placenta is a rich source of stem cells. We have discovered that stem cells from placentae affected by fetal growth restriction (FGR), a clinically significant pregnancy disorder, are morphologically and functionally different to normal placental stem cells. We predict that abnormal stem cells contribute to FGR. We will carry out gene expression and functional studies to further characterise the abnormal stem cells. The work may lead to new types of treatments for FGR in future.
Related publications (9)
Phenotypic and Functional Characterization of Mesenchymal Stem/Multipotent Stromal Cells from Decidua Basalis of Human Term Placenta
FM Abomaray, MA Al Jumah, KO Alsaad, D Jawdat, A Al Khaldi, AS AlAskar, S Al Harthy, AM Al Subayyil, T Khatlani, AO Alawad, A Alkushi, B Kalionis, MH Abumaree
A Novel Combination of Homeobox Genes Is Expressed in Mesenchymal Chorionic Stem/Stromal Cells in First Trimester and Term Pregnancies
Haiying Liu, Padma Murthi, Sharon Qin, Gina D Kusuma, Anthony J Borg, Martin Knoefler, Peter Haslinger, Ursula Manuelpillai, Mark D Pertile, Mohamed Abumaree, Bill Kalionis