Movement disorders studied in transgenic mice
Grant number: 509072 | Funding period: 2008 - 2010
We will use genetically engineered mice to study brain circuitry in an effort to understand the anatomical basis of Huntington's disease and a number of other more common degenerative brain diseases similar to Parkinson's disease. We will look at the brain in detail to decipher how the injured brain repais itself by making new connections and by producing new cells. We will also study supporting cells in the brain to determine if they play a beneficial role in this injury repair process.
Related publications (3)
Motor and behavioral phenotype in conditional mutants with targeted ablation of cortical D1 dopamine receptor-expressing cells
Luning Jiang, Claire O'Leary, Hyun Ah Kim, Clare L Parish, Jim Massalas, John L Waddington, Michelle E Ehrlich, Guenter Schuetz, Ilse Gantois, Andrew J Lawrence, John Drago
D1-dopamine receptors (Drd1a) are highly expressed in the deep layers of the cerebral cortex and the striatum. A number of human d..
Resolving pathobiological mechanisms relating to Huntington disease: Gait, balance, and involuntary movements in mice with targeted ablation of striatal D1 dopamine receptor cells
Hyun Ah Kim, Luning Jiang, Heather Madsen, Clare L Parish, Jim Massalas, Arthur Smardencas, Claire O'Leary, Ilse Gantois, Colm O'Tuathaigh, John L Waddington, Michelle E Ehrlich, Andrew J Lawrence, John Drago
Progressive cell loss is observed in the striatum, cerebral cortex, thalamus, hypothalamus, subthalamic nucleus and hippocampus in..
Phenotyping dividing cells in mouse models of neurodegenerative basal ganglia diseases
Arthur Smardencas, Kerelos Rizkalla, Hyun Ah Kim, Jim Massalas, Claire O'Leary, Michelle E Ehrlich, Guenter Schuetz, Andrew J Lawrence, John Drago
BACKGROUND: Mice generated by a Cre/LoxP transgenic paradigm were used to model neurodegenerative basal ganglia disease of which H..