A family of proteins that control stem cells in normal tissues and cancers

Grant number: 509158 | Funding period: 2008 - 2010

Completed

Abstract

This project investigates the role of a family of genes in regulating stem cells in normal tissues and cancer. This family can switch other genes off and we hypothesize that keeping these genes off is required to allow stem cells to be maintained in tissues. We combine novel studies in fruit flies and mice to examine gene function in stem cells and tumour initiation. These studies will increase our knowledge of how to manipulate stem cells and may identify new targets for tumour therapy.

Related publications (2)

Microarray profiling to analyze the effect of Snai1 loss in mouse intestinal epithelium

Gary R Hime, Katja Horvay, Thierry Jarde, Franca Casagranda, Victoria M Perreau, Helen E Abud

2015-09-01

Epithelial stem cells from a variety of tissues have been shown to express genes linked to mesenchymal cell states. The Snail fami..

Snai1 regulates cell lineage allocation and stem cell maintenance in the mouse intestinal epithelium

Katja Horvay, Thierry Jarde, Franca Casagranda, Victoria M Perreau, Katharina Haigh, Christian M Nefzger, Reyhan Akhtar, Thomas Gridley, Geert Berx, Jody J Haigh, Nick Barker, Jose M Polo, Gary R Hime, Helen E Abud

2015-05-12

Snail family members regulate epithelial-to-mesenchymal transition (EMT) during invasion of intestinal tumours, but their role in ..