A family of proteins that control stem cells in normal tissues and cancers

Grant number: 509158 | Funding period: 2008 - 2010

Completed

Abstract

This project investigates the role of a family of genes in regulating stem cells in normal tissues and cancer. This family can switch other genes off and we hypothesize that keeping these genes off is required to allow stem cells to be maintained in tissues. We combine novel studies in fruit flies and mice to examine gene function in stem cells and tumour initiation. These studies will increase our knowledge of how to manipulate stem cells and may identify new targets for tumour therapy.