Do different types of bowel cancer have different risk factors?
Grant number: 509348 | Funding period: 2008 - 2011
Colorectal cancer is Australia's most common cancer. It actually has several subtypes that probably have different causes and which may respond differently to treatment . The aim of this study is to see whether risk factors for a newly identified form of colorectal cancer, called CIMP, differ from those for the more common form of colorectal cancer. Knowing this may help us understand better how the disease is caused and so design better ways to prevent it.
Related publications (10)
Intake of Dietary Fruit, Vegetables, and Fiber and Risk of Colorectal Cancer According to Molecular Subtypes: A Pooled Analysis of 9 Studies
Akihisa Hidaka, Tabitha A Harrison, Yin Cao, Lori C Sakoda, Richard Barfield, Marios Giannakis, Mingyang Song, Amanda Phipps, Jane C Figueiredo, Syed H Zaidi, Amanda E Toland, Efrat L Amitay, Sonja Berndt, Ivan Borozan, Andrew T Chan, Steven Gallinger, Marc J Gunter, Mark A Guinter, Sophia Harlid, Heather Hampel
Protective associations of fruits, vegetables, and fiber intake with colorectal cancer risk have been shown in many, but not all e..
Exploratory Genome-Wide Interaction Analysis of Nonsteroidal Anti-inflammatory Drugs and Predicted Gene Expression on Colorectal Cancer Risk
Xiaoliang Wang, Yu-Ru Su, Paneen S Petersen, Stephanie Bien, Stephanie L Schmit, David A Drew, Demetrius Albanes, Sonja Berndt, Hermann Brenner, Peter T Campbell, Graham Casey, Jenny Cheng-Claude, Steven Gallinger, Stephen B Gruber, Robert W Haile, Tabitha A Harrison, Michael Hoffmeister, Eric J Jacobs, Mark A Jenkins, Amit D Joshi
BACKGROUND: Regular use of nonsteroidal anti-inflammatory drugs (NSAID) is associated with lower risk of colorectal cancer. Genome..
Mendelian Randomization of Circulating Polyunsaturated Fatty Acids and Colorectal Cancer Risk
Nikhil K Khankari, Barbara L Banbury, Maria C Borges, Philip Haycock, Demetrius Albanes, Volker Arndt, Sonja I Berndt, Stephane Bezieau, Hermann Brenner, Peter T Campbell, Graham Casey, Andrew T Chan, Jenny Chang-Claude, David V Conti, Michelle Cotterchio, Dallas R English, Jane C Figueiredo, Graham G Giles, Edward L Giovannucci, Marc J Gunter
BACKGROUND: Results from epidemiologic studies examining polyunsaturated fatty acids (PUFA) and colorectal cancer risk are inconsi..
Functional informed genome-wide interaction analysis of body mass index, diabetes and colorectal cancer risk
Zhiyu Xia, Yu-Ru Su, Paneen Petersen, Lihong Qi, Andre E Kim, Jane C Figueiredo, Yi Lin, Hongmei Nan, Lori C Sakoda, Demetrius Albanes, Sonja I Berndt, Stephane Bezieau, Stephanie Bien, Daniel D Buchanan, Graham Casey, Andrew T Chan, David V Conti, David A Drew, Steven J Gallinger, W James Gauderman
BACKGROUND: Body mass index (BMI) and diabetes are established risk factors for colorectal cancer (CRC), likely through perturbati..
Mendelian randomization analysis of C-reactive protein on colorectal cancer risk
Xiaoliang Wang, James Y Dai, Demetrius Albanes, Volker Arndt, Sonja I Berndt, Stephane Bezieau, Hermann Brenner, Daniel D Buchanan, Katja Butterbach, Bette Caan, Graham Casey, Peter T Campbell, Andrew T Chan, Zhengyi Chen, Jenny Chang-Claude, Michelle Cotterchio, Douglas F Easton, Graham G Giles, Edward Giovannucci, William M Grady
BACKGROUND: Chronic inflammation is a risk factor for colorectal cancer (CRC). Circulating C-reactive protein (CRP) is also modera..
Novel Common Genetic Susceptibility Loci for Colorectal Cancer
Stephanie L Schmit, Christopher K Edlund, Fredrick R Schumacher, Jian Gong, Tabitha A Harrison, Jeroen R Huyghe, Chenxu Qu, Marilena Melas, David J Van den Berg, Hansong Wang, Stephanie Tring, Sarah J Plummer, Demetrius Albanes, M Henar Alonso, Christopher I Amos, Kristen Anton, Aaron K Aragaki, Volker Arndt, Elizabeth L Barry, Sonja I Berndt
BACKGROUND: Previous genome-wide association studies (GWAS) have identified 42 loci (P < 5 × 10-8) associated with risk of colorec..
Costs and outcomes of Lynch syndrome screening in the Australian colorectal cancer population
Dayna R Cenin, Steffie K Naber, Iris Lansdorp-Vogelaar, Mark A Jenkins, Daniel D Buchanan, David B Preen, Hooi C Ee, Peter O'Leary
Background and Aim Individuals with Lynch syndrome (LS) are at increased risk of LS-related cancers including colorectal cancer (C..
Somatic mutations of the coding microsatellites within the beta-2-microglobulin gene in mismatch repair-deficient colorectal cancers and adenomas
Mark Clendenning, Alvin Huang, Harindra Jayasekara, Marie Lorans, Susan Preston, Neil O'Callaghan, Bernard J Pope, Finlay A Macrae, Ingrid M Winship, Roger L Milne, Graham G Giles, Dallas R English, John L Hopper, Aung K Win, Mark A Jenkins, Melissa C Southey, Christophe Rosty, Daniel D Buchanan
In colorectal cancers (CRCs) with tumour mismatch repair (MMR) deficiency, genes involved in the host immune response that contain..
PIK3CA Activating Mutation in Colorectal Carcinoma: Associations with Molecular Features and Survival
Christophe Rosty, Joanne P Young, Michael D Walsh, Mark Clendenning, Kristy Sanderson, Rhiannon J Walters, Susan Parry, Mark A Jenkins, Aung Ko Win, Melissa C Southey, John L Hopper, Graham G Giles, Elizabeth J Williamson, Dallas R English, Daniel D Buchanan
Mutations in PIK3CA are present in 10 to 15% of colorectal carcinomas. We aimed to examine how PIK3CA mutations relate to other mo..
Colorectal carcinomas with KRAS mutation are associated with distinctive morphological and molecular features
Christophe Rosty, Joanne P Young, Michael D Walsh, Mark Clendenning, Rhiannon J Walters, Sally Pearson, Erika Pavluk, Belinda Nagler, David Pakenas, Jeremy R Jass, Mark A Jenkins, Aung Ko Win, Melissa C Southey, Susan Parry, John L Hopper, Graham G Giles, Elizabeth Williamson, Dallas R English, Daniel D Buchanan
KRAS-mutated carcinomas comprise 35-40% of all colorectal carcinomas but little is known about their characteristics. The aim of t..