Regulation of cell signalling, proliferation and death by Lgl
Grant number: 509020 | Funding period: 2008 - 2010
Cancer is a disease that affects 1-3 people at some point in their lifetime. Therefore, understanding what causes cancer is of major importance to medical science. This proposal focuses on a group of tumour suppressors, Scrib-Dlg-Lgl, which act in a common pathway to regulate cell polarity (cell shape) and proliferation. We have shown that Lgl also regulates cell death. This proposal focuses on understanding the mechanism by which Lgl regulates the cell proliferation and death machinery.
Related publications (2)
The Salvador/Warts/Hippo pathway controls regenerative tissue growth in Drosophila melanogaster
Felix A Grusche, Joffrey L Degoutin, Helena E Richardson, Kieran F Harvey
During tissue regeneration, cell proliferation replaces missing structures to restore organ function. Regenerative potential diffe..
Lgl, aPKC, and Crumbs Regulate the Salvador/Warts/Hippo Pathway through Two Distinct Mechanisms
Nicola A Grzeschik, Linda M Parsons, Melinda L Allott, Kieran F Harvey, Helena E Richardson
BACKGROUND: The Drosophila neoplastic tumor suppressor Lethal (2) giant larvae (Lgl) controls apicobasal cell polarity and prolife..