Characterization of a novel bacterial secretion system.

Grant number: 509326 | Funding period: 2008 - 2010

Completed

Abstract

In this study we will characterize a novel bacterial secretion system that we have discovered. This sytem mediates the secretion of proteins from the bacterial cell and their attachment to the cell surface. This system is essential for the virulence of Porphyromonas gingivalis, a bacterium associated with chronic periodontitis. The chacterization of this system may offer opportunities for the development of new treatments to target this disease.

Related publications (2)

The outer membrane protein LptO is essential for the O-deacylation of LPS and the co-ordinated secretion and attachment of A-LPS and CTD proteins in Porphyromonas gingivalis

Yu-Yen Chen, Benjamin Peng, Qiaohui Yang, Michelle D Glew, Paul D Veith, Keith J Cross, Kenneth N Goldie, Dina Chen, Neil O'Brien-Simpson, Stuart G Dashper, Eric C Reynolds

2011-03-01

Protein substrates of a novel secretion system of Porphyromonas gingivalis contain a conserved C-terminal domain (CTD) essential f..

FimR and FimS: Biofilm Formation and Gene Expression in Porphyromonas gingivalis

Alvin Lo, Christine Seers, Stuart Dashper, Catherine Butler, Glenn Walker, Katrina Walsh, Deanne Catmull, Brigitte Hoffmann, Steven Cleal, Patricia Lissel, John Boyce, Eric Reynolds

2010-03-01

Porphyromonas gingivalis is a late-colonizing bacterium of the subgingival dental plaque biofilm associated with periodontitis. Tw..