How does infection with rotavirus alter the rate at which mice show diabetes?

Grant number: 509008 | Funding period: 2008 - 2010

Completed

Abstract

Rotavirus is the main cause of severe diarrhoea in children, and may contribute to progression to type 1 diabetes. We have now shown that rotavirus also modulates diabetes in mice, by a novel mechanism. In this project, the mechanism of this process will be elucidated and the capacity of human rotavirus to affect diabetes will be determined. This study will help determine the design of further human studies, and whether rotavirus vaccines also are possible modulators of diabetes development.

Related publications (5)

Scholarly works icon

Rotavirus Activates Lymphocytes from Non-Obese Diabetic Mice by Triggering Toll-Like Receptor 7 Signaling and Interferon Production in Plasmacytoid Dendritic Cells

Jessica A Pane, Nicole L Webster, Barbara S Coulson

2014-03-01

It has been proposed that rotavirus infection promotes the progression of genetically-predisposed children to type 1 diabetes, a c..

Scholarly works icon

Rotavirus acceleration of murine type 1 diabetes is associated with increased MHC class I-restricted antigen presentation by B cells and elevated proinflammatory cytokine expression by T cells

Jessica A Pane, Nicole L Webster, Christel Zufferey, Barbara S Coulson

2014-01-22

Rotavirus infection has been proposed to enhance progression towards type 1 diabetes in at-risk children. Rhesus monkey rotavirus ..

Scholarly works icon

Alteration of the Thymic T Cell Repertoire by Rotavirus Infection Is Associated with Delayed Type 1 Diabetes Development in Non-Obese Diabetic Mice

Nicole L Webster, Christel Zufferey, Jessica A Pane, Barbara S Coulson

2013-03-15

Rotaviruses are implicated as a viral trigger for the acceleration of type 1 diabetes in children. Infection of adult non-obese di..

Scholarly works icon

Rotavirus acceleration of murine type 1 diabetes is associated with a T helper 1-dependent specific serum antibody response and virus effects in regional lymph nodes

JA Pane, NL Webster, KL Graham, G Holloway, C Zufferey, BS Coulson

2013-03-01

AIMS/HYPOTHESIS: Rotavirus infection in at-risk children correlates with production of serum autoantibodies indicative of type 1 d..

Scholarly works icon

Rotavirus infection accelerates type 1 diabetes in mice with established insulitis

Kate L Graham, Natalie Sanders, Yan Tan, Janette Allison, Thomas WH Kay, Barbara S Coulson

2008-07-01

Infection modulates type 1 diabetes, a common autoimmune disease characterized by the destruction of insulin-producing islet beta ..

University of Melbourne Researchers