How does infection with rotavirus alter the rate at which mice show diabetes?
Grant number: 509008 | Funding period: 2008 - 2010
Rotavirus is the main cause of severe diarrhoea in children, and may contribute to progression to type 1 diabetes. We have now shown that rotavirus also modulates diabetes in mice, by a novel mechanism. In this project, the mechanism of this process will be elucidated and the capacity of human rotavirus to affect diabetes will be determined. This study will help determine the design of further human studies, and whether rotavirus vaccines also are possible modulators of diabetes development.
Related publications (5)
Rotavirus Activates Lymphocytes from Non-Obese Diabetic Mice by Triggering Toll-Like Receptor 7 Signaling and Interferon Production in Plasmacytoid Dendritic Cells
Jessica A Pane, Nicole L Webster, Barbara S Coulson
It has been proposed that rotavirus infection promotes the progression of genetically-predisposed children to type 1 diabetes, a c..
Rotavirus acceleration of murine type 1 diabetes is associated with increased MHC class I-restricted antigen presentation by B cells and elevated proinflammatory cytokine expression by T cells
Jessica A Pane, Nicole L Webster, Christel Zufferey, Barbara S Coulson
Rotavirus infection has been proposed to enhance progression towards type 1 diabetes in at-risk children. Rhesus monkey rotavirus ..
Alteration of the Thymic T Cell Repertoire by Rotavirus Infection Is Associated with Delayed Type 1 Diabetes Development in Non-Obese Diabetic Mice
Nicole L Webster, Christel Zufferey, Jessica A Pane, Barbara S Coulson
Rotaviruses are implicated as a viral trigger for the acceleration of type 1 diabetes in children. Infection of adult non-obese di..
Rotavirus acceleration of murine type 1 diabetes is associated with a T helper 1-dependent specific serum antibody response and virus effects in regional lymph nodes
JA Pane, NL Webster, KL Graham, G Holloway, C Zufferey, BS Coulson
AIMS/HYPOTHESIS: Rotavirus infection in at-risk children correlates with production of serum autoantibodies indicative of type 1 d..
Rotavirus infection accelerates type 1 diabetes in mice with established insulitis
Kate L Graham, Natalie Sanders, Yan Tan, Janette Allison, Thomas WH Kay, Barbara S Coulson
Infection modulates type 1 diabetes, a common autoimmune disease characterized by the destruction of insulin-producing islet beta ..