How placental malaria causes fetal growth restriction

Grant number: 509185 | Funding period: 2008 - 2010

Completed

Abstract

Malaria infection in the placenta impairs the baby's growth, probably by causing placental inflammation. We believe this inflammation interferes with the ability of placental cells to transport nutrients such as amino acids and glucose from mother to baby. We will test this by examining the expression of genes and proteins involved in nutrient transport in placental samples from pregnant women, and in cell lines, and will examine how malaria affects growth factors that control this process.

Related publications (8)

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Impaired placental autophagy in placental malaria

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Inhibition of placental mTOR signaling provides a link between placental malaria and reduced birthweight

Kris Genelyn Dimasuay, Elizabeth H Aitken, Fredrick Rosario, Madi Njie, Jocelyn Glazier, Stephen J Rogerson, Freya JI Fowkes, James G Beeson, Theresa Powell, Thomas Jansson, Philippe Boeuf

2017-01-03

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Insight Into the Pathogenesis of Fetal Growth Restriction in Placental Malaria: Decreased Placental Glucose Transporter Isoform 1 Expression

Upeksha P Chandrasiri, Caroline LL Chua, Alexandra J Umbers, Ebbie Chaluluka, Jocelyn D Glazier, Stephen J Rogerson, Philippe Boeuf

2014-05-15

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Plasmodium falciparum Malaria Elicits Inflammatory Responses that Dysregulate Placental Amino Acid Transport

Philippe Boeuf, Elizabeth H Aitken, Upeksha Chandrasiri, Caroline Lin Lin Chua, Bernie McInerney, Leon McQuade, Michael Duffy, Malcolm Molyneux, Graham Brown, Jocelyn Glazier, Stephen J Rogerson

2013-02-01

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Does Malaria Affect Placental Development? Evidence from In Vitro Models

Alexandra J Umbers, Danielle I Stanisic, Maria Ome, Regina Wangnapi, Sarah Hanieh, Holger W Unger, Leanne J Robinson, Elvin Lufele, Francesca Baiwog, Peter M Siba, Christopher L King, James G Beeson, Ivo Mueller, John D Aplin, Jocelyn D Glazier, Stephen J Rogerson

2013-01-31

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Plasmodium falciparum malaria elicits inflammatory responses that dysregulate placental amino acid transport

PS Boeuf, E AITKEN, UP Chandrasiri, L CHUA, null McInerney, null McQuade, M Duffy, null Molyneux, GV Brown, null Glazier, SJ Rogerson

2013-01-01

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Relevant Assay to Study the Adhesion of Plasmodium falciparum-Infected Erythrocytes to the Placental Epithelium

Philippe Boeuf, Wina Hasang, Eric Hanssen, Jocelyn D Glazier, Stephen J Rogerson

2011-06-24

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Placental Malaria-Associated Inflammation Disturbs the Insulin-like Growth Factor Axis of Fetal Growth Regulation

Alexandra J Umbers, Philippe Boeuf, Caroline Clapham, Danielle I Stanisic, Francesca Baiwog, Ivo Mueller, Peter Siba, Christopher L King, James G Beeson, Jocelyn Glazier, Stephen J Rogerson

2011-02-15