Understanding the recognition requirements for virus-specific T cells
Grant number: 508929 | Funding period: 2008 - 2010
Viral infection results in the activation and proliferation of T cells that eradicate infected cells. Recognition of infected cells is meditated by presentation and recognition of viral protein fragments via specific cell surface receptors. This proposal plans to examine the factors that determine the diversity of the immune response and the consequences of such diversity on anti-viral immunity. This has implications for the development of vaccines.
Related publications (6)
Secreted HLA recapitulates the immunopeptidome and allows in-depth coverage of HLA A*02:01 ligands
Katherine E Scull, Nadine L Dudek, Alexandra J Corbett, H Ramarathinam, Dhana G Gorasia, Nicholas A Williamson, Anthony W Purcell
HLA molecules are cell-surface glycoproteins that present peptides, derived from intracellular protein antigens, for surveillance ..
Structural basis for enabling T-cell receptor diversity within biased virus-specific CD8( ) T-cell responses
E Bridie Day, Carole Guillonneau, Stephanie Gras, Nicole L La Gruta, Dario AA Vignali, Peter C Doherty, Anthony W Purcell, Jamie Rossjohn, Stephen J Turner
Pathogen-specific responses are characterized by preferred profiles of peptide+class I MHC (pMHCI) glycoprotein-specific T-cell re..
Direct quantitation of MHC-bound peptide epitopes by selected reaction monitoring
Chor Teck Tan, Nathan P Croft, Nadine L Dudek, Nicholas A Williamson, Anthony W Purcell
We describe a cell-free approach that employs selected reaction monitoring (SRM) in tandem mass spectrometry to identify and quant..
A novel strategy for the targeted analysis of protein and peptide metabolites
Nicholas A Williamson, Charles Reilly, Chor-Teck Tan, Sri-Harsha Ramarathinam, Alun Jones, Christie L Hunter, Francis R Rooney, Anthony W Purcell
In many biological applications such as epitope discovery or drug metabolism studies, the detection of naturally processed exogeno..
Complete modification of TCR specificity and repertoire selection does not perturb a CD8( ) T cell immunodominance hierarchy
Katherine Kedzierska, Carole Guillonneau, Stephanie Gras, Lauren A Hatton, Richard Webby, Anthony W Purcell, Jamie Rossjohn, Peter C Doherty, Stephen J Turner
Understanding T cell immunodominance hierarchies is fundamental to the development of cellular-based vaccines and immunotherapy. A..