Targeting Cell Division to Increase Response to Chemotherapy and Radiotherapy

Abstract

The use of chemotherapy for the treatment of cancer has improved outcomes in many types of cancer. Recent reserach has uncovered how and why cancer cells respond to chemotherapy. This reserach proposal will use this knowledge to evaluate a new approach to cancer treatment by targeting a process called cell cycle checkpoints. Specifically this proposal will evaluate the difference between normal cells and cancer cells and use imaging to examine response to these new treatments.