Brain development during adolescence and the emergence of depression: A longitudinal MRI study.
Grant number: DP0878136 | Funding period: 2008 - 2012
Traditionally mental health services have focused on established disorders. Whilst significant gains in outcomes have been obtained in other areas of health by focusing on early intervention and prevention, in the mental health field this approach has been limited by the inability to predict who is likely to go on to develop serious mental disorder. This study will provide critical information for understanding the risk processes that are operating during the critical phase of early adolescence, and will therefore make a fundamental contribution to our understanding of who, and what, to target in early intervention and prevention strategies.
Related publications (42)
The long-term associations between parental behaviors, cognitive function and brain activation in adolescence
Orwa Dandash, Nicolas Cherbuin, Orli Schwartz, Nicholas B Allen, Sarah Whittle
Parenting behavior has a vital role in the development of the brain and cognitive abilities of offspring throughout childhood and ..
Unraveling the Consequences of Childhood Maltreatment: Deviations From Typical Functional Neurodevelopment Mediate the Relationship Between Maltreatment History and Depressive Symptoms
Divyangana Rakesh, Clare Kelly, Nandita Vijayakumar, Andrew Zalesky, Nicholas B Allen, Sarah Whittle
BACKGROUND: Childhood maltreatment is associated with lifelong psychiatric sequelae. However, our understanding of neurobiological..
Associations between early life stress and anterior pituitary gland volume development - A novel index of long-term hypothalamic-pituitary-adrenal axis functioning
Carmela Diaz-Arteche, Julian G Simmons, Despina E Ganella, Orli Schwartz, Jee Hyun Kim, Paige Farrow, Sarah Whittle
Previous research has established associations between early life stress (ELS) and altered pituitary gland volume (PGV) growth dur..
Early Adolescent Drinking and Cannabis Use Predicts Later Sleep-Quality Problems
Rowan P Ogeil, Ali Cheetham, Anna Mooney, Nicholas B Allen, Orli Schwartz, Michelle L Byrne, Julian G Simmons, Sarah Whittle, Dan Lubman
A range of biopsychosocial changes occur during adolescence that contribute to changes in the sleep-wake system. Use of alcohol an..
Brain-derived neurotrophic factor DNA methylation mediates the association between neighborhood disadvantage and adolescent brain structure
Jo Wrigglesworth, Joanne Ryan, Nandita Vijayakumar, Sarah Whittle
Prior research indicates that socioeconomic disadvantage is associated with prefrontal cortical (PFC) development in childhood and..
Childhood maltreatment, pituitary volume and adolescent hypothalamic-pituitary-adrenal axis -Evidence for a maltreatment-related attenuation
Michael Kaess, Sarah Whittle, Laurie O'Brien-Simpson, Nicholas B Allen, Julian G Simmons
BACKGROUND: Alterations of the development of the hypothalamic-pituitary-adrenal axis (HPAA) have been suggested to be related to ..
Family meta-emotion and the onset of major depressive disorder in adolescence: A prospective longitudinal study
Orli S Schwartz, Vanessa J Rowell, Sarah Whittle, Michelle L Byrne, Julian G Simmons, Lisa Sheeber, Vicki McKenzie, Nicholas B Allen
Meta-emotion philosophy refers to an organized set of thoughts, reactions, and feelings about one's emotions and the emotions of o..
Amygdala volume mediates the relationship between externalizing symptoms and daily smoking in adolescence: A prospective study
Ali Cheetham, Nicholas B Allen, Sarah Whittle, Julian Simmons, Murat Yucel, Dan Lubman
The current study examined amygdala and orbitofrontal cortex (OFC) volumes as mediators of the relationship between externalizing ..
Development of subcortical volumes across adolescence in males and females: A multisample study of longitudinal changes
Megan M Herting, Cory Johnson, Kathryn L Mills, Nandita Vijayakumar, Meg Dennison, Chang Liu, Anne-Lise Goddings, Ronald E Dahl, Elizabeth R Sowell, Sarah Whittle, Nicholas B Allen, Christian K Tamnes
The developmental patterns of subcortical brain volumes in males and females observed in previous studies have been inconsistent. ..
Duration of Breastfeeding and Subsequent Adolescent Obesity: Effects of Maternal Behavior and Socioeconomic Status
Michelle L Byrne, Orli S Schwartz, Julian G Simmons, Lisa Sheeber, Sarah Whittle, Nicholas B Allen
PURPOSE: Previous research has shown that longer duration of breastfeeding is associated with less risk of obesity in childhood an..
Adolescent temperament dimensions as stable prospective risk and protective factors for salivary C-reactive protein
Benjamin W Nelson, Michelle L Byrne, Julian G Simmons, Sarah Whittle, Orli S Schwartz, Neil M O'Brien-Simpson, Katrina A Walsh, Eric C Reynolds, Nicholas B Allen
OBJECTIVE: Temperament has associations with later physical health outcomes, yet there is a dearth of research exploring the conne..
Longitudinal Bi-directional Effects of Disordered Eating, Depression and Anxiety
Francis Puccio, Matthew Fuller-Tyszkiewicz, George Youssef, Sarah Mitchell, Michelle Byrne, Nick Allen, Isabel Krug
OBJECTIVE: The present study aims to explore the potentially longitudinal bi-directional effects of disordered eating (DE) symptom..
Cortico-amygdalar maturational coupling is associated with depressive symptom trajectories during adolescence
Nandita Vijayakumar, Nicholas B Allen, Meg Dennison, Michelle L Byrne, Julian G Simmons, Sarah Whittle
BACKGROUND: Adolescence is characterized by increasing prevalence of depressive symptomatology, along with significant structural ..
Longitudinal Trajectories of Depression Symptoms in Adolescence: Psychosocial Risk Factors and Outcomes
Rachel ER Ellis, Marc L Seal, Julian G Simmons, Sarah Whittle, Orli S Schwartz, Michelle L Byrne, Nicholas B Allen
Variations in symptom trajectories within a population may represent distinct groups with different etiologies and outcomes. This ..
Role of Positive Parenting in the Association Between Neighborhood Social Disadvantage and Brain Development Across Adolescence
Sarah Whittle, Nandita Vijayakumar, Julian G Simmons, Meg Dennison, Orli Schwartz, Christos Pantelis, Lisa Sheeber, Michelle L Byrne, Nicholas B Allen
Importance: The negative effects of socioeconomic disadvantage on lifelong functioning are pronounced, with some evidence suggesti..
Physiological correlates of emotional reactivity and regulation in early adolescents
Melissa D Latham, Nina Cook, Julian G Simmons, Michelle L Byrne, Jonathan WL Kettle, Orli Schwartz, Nandita Vijayakumar, Sarah Whittle, Nicholas B Allen
Few studies have examined physiological correlates of emotional reactivity and regulation in adolescents, despite the occurrence i..
Affective Parenting Behaviors, Adolescent Depression, and Brain Development: A Review of Findings From the Orygen Adolescent Development Study
Orli S Schwartz, Julian G Simmons, Sarah Whittle, Michelle L Byrne, Marie BH Yap, Lisa B Sheeber, Nicholas B Allen
Parenting plays a multifaceted role in adolescent development. In this article, we review studies based on an observational assess..
Brain connectivity networks and longitudinal trajectories of depression symptoms in adolescence
Rachel Ellis, Marc L Seal, Christopher Adamson, Richard Beare, Julian G Simmons, Sarah Whittle, Nicholas B Allen
High levels of depression during adolescence may contribute to the risk for future depression later in life. This study examined t..
Childhood maltreatment, psychopathology, and the development of hippocampal subregions during adolescence
Sarah Whittle, Julian G Simmons, Sylke Hendriksma, Nandita Vijayakumar, Michelle L Byrne, Meg Dennison, Nicholas B Allen
INTRODUCTION: It is well established that childhood maltreatment has a detrimental impact on the brain, particularly the hippocamp..
Trajectories of adolescent conduct problems in relation to cortical thickness development: a longitudinal MRI study
S Oostermeijer, S Whittle, C Suo, NB Allen, JG Simmons, N Vijayakumar, PM van de Ven, LMC Jansen, M Yucel, A Popma
Multiple cross-sectional imaging studies have identified structural abnormalities in prefrontal, temporal and limbic regions relat..
Brain Development During Adolescence: A Mixed-Longitudinal Investigation of Cortical Thickness, Surface Area, and Volume
Nandita Vijayakumar, Nicholas B Allen, George Youssef, Meg Dennison, Murat Yucel, Julian G Simmons, Sarah Whittle
What we know about cortical development during adolescence largely stems from analyses of cross-sectional or cohort-sequential sam..
Observed Measures of Negative Parenting Predict Brain Development during Adolescence
Sarah Whittle, Nandita Vijayakumar, Meg Dennison, Orli Schwartz, Julian G Simmons, Lisa Sheeber, Nicholas B Allen
Limited attention has been directed toward the influence of non-abusive parenting behaviour on brain structure in adolescents. It ..
Linking the Serotonin Transporter Gene, Family Environments, Hippocampal Volume and Depression Onset: A Prospective Imaging Gene X Environment Analysis
Keriann Little, Craig A Olsson, George J Youssef, Sarah Whittle, Julian G Simmons, Murat Yuecel, Lisa B Sheeber, Debra L Foley, Nicholas B Allen
A single imaging gene-environment (IGxE) framework that is able to simultaneously model genetic, neurobiological, and environmenta..
Dual-Axis Hormonal Covariation in Adolescence and the Moderating Influence of Prior Trauma and Aversive Maternal Parenting
Julian G Simmons, Michelle L Byrne, Orli S Schwartz, Sarah L Whittle, Lisa Sheeber, Michael Kaess, George J Youssef, Nicholas B Allen
Adversity early in life can disrupt the functioning of the hypothalamic-pituitary-adrenal and hypothalamic-pituitary-gonadal axes ..
Dispositional mindfulness is predicted by structural development of the insula during late adolescence
S Friedel, SL Whittle, N Vijayakumar, JG Simmons, ML Byrne, OS Schwartz, NB Allen
Adolescence is a critical period of development, in which the increasing social and cognitive demands of independence need to be m..
Attention to pleasant stimuli in early adolescence predicts alcohol-related problems in mid-adolescence
Joshua BB Garfield, Nicholas B Allen, Ali Cheetham, Julian G Simmons, Dan I Lubman
Attenuated responses to natural rewards have been found to predict subsequent substance use among dependent populations, suggestin..
Functional brain-imaging correlates of negative affectivity and the onset of first-episode depression
CG Davey, S Whittle, BJ Harrison, JG Simmons, ML Byrne, OS Schwartz, NB Allen
BACKGROUND: The amygdala and subgenual anterior cingulate cortex (sACC) are key brain regions for the generation of negative affec..
The influence of sex, temperament, risk-taking and mental health on the emergence of gambling: a longitudinal study of young people
Murat Yuecel, Sarah Whittle, George J Youssef, Himani Kashyap, Julian G Simmons, Orli Schwartz, Dan I Lubman, Nicholas B Allen
There are a host of complex and interlinked psychological, social and biological factors involved in the development of problem ga..
Early life stress alters pituitary growth during adolescence-A longitudinal study
Despina E Ganella, Nicholas B Allen, Julian G Simmons, Orli Schwartz, Jee Hyun Kim, Lisa Sheeber, Sarah Whittle
The pituitary gland is integral in mediating the stress-response via its role in hypothalamic-pituitary-adrenal (HPA) axis functio..
Trait positive affect is associated with hippocampal volume and change in caudate volume across adolescence
Meg Dennison, Sarah Whittle, Murat Yuecel, Michelle L Byrne, Orli Schwartz, Julian G Simmons, Nicholas B Allen
Trait positive affect (PA) in childhood confers both risk and resilience to psychological and behavioral difficulties in adolescen..
Association between serotonin transporter genotype, brain structure and adolescent-onset major depressive disorder: a longitudinal prospective study
K Little, CA Olsson, S Whittle, GJ Youssef, ML Byrne, JG Simmons, M Yuecel, DL Foley, NB Allen
The extent to which brain structural abnormalities might serve as neurobiological endophenotypes that mediate the link between the..
Development of temperamental effortful control mediates the relationship between maturation of the prefrontal cortex and psychopathology during adolescence: A 4-year longitudinal study
Nandita Vijayakumar, Sarah Whittle, Meg Dennison, Murat Yuecel, Julian Simmons, Nicholas B Allen
This study investigated the relationship between the development of effortful control (EC), a temperamental measure of self-regula..
Positive parenting predicts the development of adolescent brain structure: A longitudinal study
Sarah Whittle, Julian G Simmons, Meg Dennison, Nandita Vijayakumar, Orli Schwartz, Marie BH Yap, Lisa Sheeber, Nicholas B Allen
Little work has been conducted that examines the effects of positive environmental experiences on brain development to date. The a..
Sex-specific prediction of hypothalamic-pituitary-adrenal axis activity by pituitary volume during adolescence: A longitudinal study from 12 to 17 years of age
Michael Kaess, Julian G Simmons, Sarah Whittle, Martina Jovev, Andrew M Chanen, Murat Yuecel, Christos Pantelis, Nicholas B Allen
OBJECTIVE: To investigate the longitudinal relationship between pituitary gland volume (PGV) and parameters of hypothalamic-pituit..
Mapping subcortical brain maturation during adolescence: evidence of hemisphere- and sex-specific longitudinal changes
Meg Dennison, Sarah Whittle, Murat Yuecel, Nandita Vijayakumar, Alexandria Kline, Julian Simmons, Nicholas B Allen
Early to mid-adolescence is an important developmental period for subcortical brain maturation, but longitudinal studies of these ..
Maternal Parenting Behaviors and Adolescent Depression: The Mediating Role of Rumination
Michael A Gate, Edward R Watkins, Julian G Simmons, Michelle L Byrne, Orli S Schwartz, Sarah Whittle, Lisa B Sheeber, Nicholas B Allen
Substantial evidence suggests that rumination is an important vulnerability factor for adolescent depression. Despite this, few st..
Orbitofrontal Volumes in Early Adolescence Predict Initiation of Cannabis Use: A 4-Year Longitudinal and Prospective Study
Ali Cheetham, Nicholas B Allen, Sarah Whittle, Julian G Simmons, Murat Yuecel, Dan I Lubman
BACKGROUND: There is growing evidence that long-term, heavy cannabis use is associated with alterations in regional brain volumes...
Emotional Inertia Prospectively Predicts the Onset of Depressive Disorder in Adolescence
Peter Kuppens, Lisa B Sheeber, Marie BH Yap, Sarah Whittle, Julian G Simmons, Nicholas B Allen
Emotional inertia refers to the degree to which a person's current emotional state is predicted by their prior emotional state, re..
Cerebellar white-matter changes in cannabis users with and without schizophrenia
N Solowij, M Yuecel, C Respondek, S Whittle, E Lindsay, C Pantelis, DI Lubman
BACKGROUND: The cerebellum is rich in cannabinoid receptors and implicated in the neuropathology of schizophrenia. Long-term canna..
Observed maternal responses to adolescent behaviour predict the onset of major depression
Orli S Schwartz, Paul Dudgeon, Lisa B Sheeber, Marie BH Yap, Julian G Simmons, Nicholas B Allen
Two mechanisms have been proposed regarding relations between parental responses to adolescent affective behaviours and the develo..
Pituitary volume prospectively predicts internalizing symptoms in adolescence
Amy R Zipursky, Sarah Whittle, Murat Yuecel, Valentina Lorenzetti, Stephen J Wood, Dan I Lubman, Julian G Simmons, Nicholas B Allen
BACKGROUND: Early adolescence is a critical time for the development of both internalizing and externalizing disorders. We aimed t..