CJ MARTIN OVERSEAS BIOMEDICAL FELLOWSHIP - ARTIFICIALLY EVOLVING HUMAN RECEPTOR PROTEINS
Grant number: 520309 | Funding period: 2008 - 2013
Approximately half of all prescription drugs on the market act on G protein coupled receptors (GPCRs). The mechanisms underlying GPCR function are mainly unknown due to a lack of structural information. No solved structures exist for any of the estimated 800 human GPCRs, making it difficult to design new drugs. By applying advanced protein engineering techniques I aim to produce human GPCRs in bacteria to ultimately acquire structural information, which will enable novel drug development.
Related publications (4)
Improving the apo-state detergent stability of NTS1 with CHESS for pharmacological and structural studies
Daniel J Scott, Lutz Kummer, Pascal Egloff, Ross AD Bathgate, Andreas Plueckthun
The largest single class of drug targets is the G protein-coupled receptor (GPCR) family. Modern high-throughput methods for drug ..