Evaluation of new imaging approaches in Alzheimer's disease
Grant number: 509166 | Funding period: 2008 - 2010
Alzheimer's disease is the most common age-related neurodegenerative disease, and the most common cause of dementia. It is estimated that 212,000 Australians suffer from dementia and this will rise to approximately 730,000 by 2050. Currently there are no definitive diagnostic methods for AD. The research proposed in this application describes the evaluation of a new imaging radiotracer that would be suitable for widespread non-invasive diagnosis of AD.
Related publications (9)
A beta imaging with 18F-florbetaben in prodromal Alzheimer's disease: a prospective outcome study
Kevin T Ong, Victor L Villemagne, Alex Bahar-Fuchs, Fiona Lamb, Narelle Langdon, Ana M Catafau, Andrew W Stephens, John Seibyl, Ludger M Dinkelborg, Cornelia B Reininger, Barbara Putz, Beate Rohde, Colin L Masters, Christopher C Rowe
BACKGROUND: We assessed the clinical utility of β-amyloid (Aβ) imaging with (18)F-florbetaben (FBB) in mild cognitive impairment (..
F-18-florbetaben A beta imaging in mild cognitive impairment
Kevin Ong, Victor L Villemagne, Alex Bahar-Fuchs, Fiona Lamb, Gael Chetelat, Parnesh Raniga, Rachel S Mulligan, Olivier Salvado, Barbara Putz, Katrin Roth, Colin L Masters, Cornelia B Reininger, Christopher C Rowe
INTRODUCTION: (18)F-florbetaben and positron emission tomography were used to examine the relationships between β-amyloid (Aβ) dep..
In vitro characterization of [F-18]-florbetaben, an A beta imaging radiotracer
Michelle T Fodero-Tavoletti, Damian Brockschnieder, Victor L Villemagne, Lucas Martin, Andrea R Connor, Andrea Thiele, Mathias Berndt, Catriona A McLean, Sabine Krause, Christopher C Rowe, Colin L Masters, Ludger Dinkelborg, Thomas Dyrks, Roberto Cappai
PURPOSE: Amyloid-β (Aβ) plaques are a major pathological hallmark of Alzheimer's disease (AD). The noninvasive detection of Aβ pla..
Comparison of C-11-PiB and F-18-florbetaben for A beta imaging in ageing and Alzheimer's disease
Victor L Villemagne, Rachel S Mulligan, Svetlana Pejoska, Kevin Ong, Gareth Jones, Graeme O'Keefe, J Gordon Chan, Kenneth Young, Henri Tochon-Danguy, Colin L Masters, Christopher C Rowe
PURPOSE: Amyloid imaging with (18)F-labelled radiotracers will allow widespread use of this technique, facilitating research, diag..
Amyloid Imaging with F-18-Florbetaben in Alzheimer Disease and Other Dementias
Victor L Villemagne, Kevin Ong, Rachel S Mulligan, Gerhard Holl, Svetlana Pejoska, Gareth Jones, Graeme O'Keefe, Uwe Ackerman, Henri Tochon-Danguy, J Gordon Chan, Cornelia B Reininger, Lueder Fels, Barbara Putz, Beate Rohde, Colin L Masters, Christopher C Rowe
UNLABELLED: Amyloid imaging with (18)F-labeled radiotracers will allow widespread use, facilitating research, diagnosis, and thera..
The ART of loss: A beta imaging in the evaluation of Alzheimer's disease and other dementias
Victor L Villemagne, Michelle T Fodero-Tavoletti, Kerryn E Pike, Roberto Cappai, Colin L Masters, Christopher C Rowe
Molecular neuroimaging based on annihilation radiation tomographic (ART) techniques such as positron emission tomography (PET), in..