WHICH TRANSGENIC PIG WILL BE USED FOR ISLET TRANSPLANTATION IN HUMANS?
Grant number: 447718 | Funding period: 2007 - 2013
We propose that xenotransplantation of pig islets will cure Type 1 diabetes. This program will generate genetically modified pigs to overcome the molecular differences between pigs and humans by removing a pig gene and inserting several human genes. In addition, we will add immunosuppressive genes and so minimise the need for drug treatment of the diabetic recipient. We will test our hypothesis by transplanting islets from these genetically modified pigs into baboons. We suggest that this will provide an inexhaustible supply of islets for transplantation.
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BACKGROUND: We investigated whether graft produced anti-human CD2, mediated by adenovirus (Adv) transduction of pig neonatal islet..
Unlike CD4( ) T-cell help, CD28 costimulation is necessary for effective primary CD8( ) T-cell influenza-specific immunity
Shirley GK Seah, Emma M Carrington, Wy C Ng, Gabrielle T Belz, Jamie L Brady, Robyn M Sutherland, Manuela S Hancock, Nicole L La Gruta, Lorena E Brown, Stephen J Turner, Yifan Zhan, Andrew M Lew
The importance of costimulation on CD4(+) T cells has been well documented. However, primary CTLs against many infections includi..