Novel Models for Gastrointestinal Disease, Physiology and Development

Abstract

DESCRIPTION (provided by applicant): The overall aims of this proposal are to produce and characterise new mutant mouse strains that will be applicable to the study of diseases and biology of the gut and allow the identification of genes involved in regulating these processes. Inflammatory diseases of the gut including ulcerative colitis, Crohn's disease and gastritis are the result of a destructive inflammatory response. Despite recent advances, the basis for these diseases remains unclear and we know little about the normal molecular mechanisms that control inflammation in the gut. The events that underlie the cell development in gut epithelia are poorly understood, as are the pathological..

Related publications (1)

Random mutagenesis of the mouse genome: A strategy for discovering gene function and the molecular basis of disease

N Nguyen, LM Judd, A Kalantzis, B Whittle, AS Giraud, IR Van Driel

2011-01-01

Mutagenesis of mice with N-ethyl-N-nitrosourea (ENU) is a phenotype-driven approach to unravel gene function and discover new biol..