INFLUENCES OF OESTROGEN ON NEURODEGNERATION AND BEHAVIOURS
Grant number: 494813 | Funding period: 2008 - 2010
More women develop Alzheimer's disease whereas more men develop Parkinson's disease. This study will try to understand whether sex hormones play a part in the devlopment of these diseases. This study will also try to answer how the female sex hormone, oestrogen, influences behaviour and or development of mental health problems such as depression and obsessive-compulsive disorder.
Related publications (6)
Estrogens do not protect, but androgens exacerbate, collagen accumulation in the female mouse kidney after ureteric obstruction
Tim D Hewitson, Wah Chin Boon, Evan R Simpson, Edward R Smith, Chrishan S Samuel
AIMS: Controversy surrounds the gender basis of progression in chronic kidney disease. Unfortunately, most experimental studies ad..
Hepatic Glucose Intolerance Precedes Hepatic Steatosis in the Male Aromatase Knockout (ArKO) Mouse
Michelle L Van Sinderen, Gregory R Steinberg, Sebastian B Jorgensen, Sarah Q To, Kevin C Knower, Colin D Clyne, Jane Honeyman, Jenny D Chow, Kerrie A Herridge, Margaret EE Jones, Evan R Simpson, Wah Chin Boon
Estrogens are known to play a role in modulating metabolic processes within the body. The Aromatase knockout (ArKO) mice have been..
Behavioural phenotype of APPC100.V717F transgenic mice over-expressing a mutant A beta-bearing fragment is associated with reduced NMDA receptor density
Wah Chin Boon, Maarten van den Buuse, Nico Wegener, Sally Martin, Hui Kheng Chua, Ashley I Bush, Colin L Masters, Paul A Adlard, Qiao-Xin Li
The aim of this study was to characterize APPC100.V717F transgenic (TgC100.V717F) mice which over-express a mutant C100 fragment o..
Estrogen deficiency results in apoptosis in the frontal cortex of adult female aromatase knockout mice
Rachel A Hill, Hui Kheng Chua, Margaret EE Jones, Evan R Simpson, Wah Chin Boon
The aromatase knockout (ArKO) mouse is completely estrogen deficient. We previously detected apoptosis in the hypothalamus of 1 ye..