INVESTIGATING THE ROLE OF TCR AVIDITY IN INFLUENZA VIRUS-SPECIFIC CD8 T CELL RESPONSES

Grant number: 520643 | Funding period: 2008 - 2011

Completed

Abstract

One of the constituents of the immune system is the cytotoxic, or killer, T cells and these are important in the overall protection from viral infection. Activation of these T cells is mediated by signalling through the T cell receptor (TCR). This study will definitively determine how the strength with which the TCR binds to the activating ligand, can influence the quality of virus-specific T cell immune responses after infection. This has implications for vaccine design.