INVESTIGATING THE ROLE OF TCR AVIDITY IN INFLUENZA VIRUS-SPECIFIC CD8 T CELL RESPONSES
Grant number: 520643 | Funding period: 2008 - 2011
One of the constituents of the immune system is the cytotoxic, or killer, T cells and these are important in the overall protection from viral infection. Activation of these T cells is mediated by signalling through the T cell receptor (TCR). This study will definitively determine how the strength with which the TCR binds to the activating ligand, can influence the quality of virus-specific T cell immune responses after infection. This has implications for vaccine design.
Related publications (5)
Heightened self-reactivity associated with selective survival, but not expansion, of naive virus-specific CD8( ) T cells in aged mice
Kylie M Quinn, Sophie G Zaloumis, Tania Cukalac, Wan-Ting Kan, Xavier YX Sng, Michiko Mirams, Katherine A Watson, James M McCaw, Peter C Doherty, Paul G Thomas, Andreas Handel, Nicole L La Gruta
Diversity and clonotypic composition of influenza-specific CD8( ) TCR repertoires remain unaltered in the absence of Aire
Katherine Kedzierska, Sophie A Valkenburg, Carole Guillonneau, Francois-Xavier Hubert, Tania Cukalac, Joan M Curtis, John Stambas, Hamish S Scott, Lukasz Kedzierski, Vanessa Venturi, Miles P Davenport