New drugs targeting tumours and blindness
Grant number: 566911 | Funding period: 2009 - 2011
Understanding blood vessel growth has profound clinical implications for many diseases. Blocking vessel growth is a promising strategy for treatment of cancer and eye complications accompanying diabetes, whereas treatments to stimulate new vessel growth will treat ischemic disorders ie. heart attack and stroke. Here we investigate whether targeting an enzyme that grows blood vessels has potential for making drugs to stop tumor growth or eye damage that occurs with diabetes and premature births.
Related publications (3)
Transforming growth factor-beta 1 requires NADPH oxidase 4 for angiogenesis in vitro and in vivo
Hitesh M Peshavariya, Elsa C Chan, Guei Sheung Liu, Fan Jiang, Gregory J Dusting
Angiogenesis, the formation of new blood vessels, is a key physiological event in organ development and tissue responses to hypoxi..
Involvement of Nox2 NADPH Oxidase in Retinal Neovascularization
Elsa C Chan, Peter van Wijngaarden, Guei-Sheung Liu, Fan Jiang, Hitesh Peshavariya, Gregory J Dusting
PURPOSE: The proliferation of new blood vessels in the retina is a leading cause of vision impairment. Nicotinamide adenine dinucl..