Gastrin, Iron and Colorectal Cancer

Grant number: 566555 | Funding period: 2009 - 2011

Completed

Abstract

Our objective is to understand the biological significance of the interaction between iron and the hormone gastrin. The project's significance to human health lies in the fact that gastrins stimulate growth of the lining of the stomach and colon, accelerate the development of gastrointestinal cancers, and may be involved in iron homeostasis. Recognition that iron is essential for the biological activity of gastrins may allow the development of novel therapies for colon cancer and iron overload.

Related publications (5)

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Zinc ions upregulate the hormone gastrin via an E-box motif in the proximal gastrin promoter

Lin Xiao, Suzana Kovac, Mike Chang, Arthur Shulkes, Graham S Baldwin, Oneel Patel

2014-02-01

Gastrin and its precursors act as growth factors for the normal and neoplastic gastrointestinal mucosa. As the hypoxia mimetic cob..

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The Role of Hypoxia-Inducible Factor 1 alpha in Determining the Properties of Castrate-Resistant Prostate Cancers

Weranja KB Ranasinghe, Lin Xiao, Suzana Kovac, Mike Chang, Carine Michiels, Damien Bolton, Arthur Shulkes, Graham S Baldwin, Oneel Patel

2013-01-16

BACKGROUND: Castrate-resistant prostate cancer (CRPC) is a lethal condition in patients receiving androgen deprivation therapy for..

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Induction of Gastrin Expression in Gastrointestinal Cells by Hypoxia or Cobalt Is Independent of Hypoxia-Inducible Factor (HIF)

Lin Xiao, Suzana Kovac, Mike Chang, Arthur Shulkes, Graham S Baldwin, Oneel Patel

2012-07-01

Gastrin and its precursors have been shown to promote mitogenesis and angiogenesis in gastrointestinal tumors. Hypoxia stimulates ..

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Bismuth ions inhibit the biological activity of non-amidated gastrins in vivo

Suzana Kovac, Su-Wen Loh, Shamilah Lachal, Arthur Shulkes, Graham S Baldwin

2012-02-15

The peptide hormone gastrin binds two ferric ions with high affinity, and iron binding is essential for the biological activity of..

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Definition of the residues required for the interaction between glycine-extended gastrin and transferrin in vitro

Suzana Kovac, Audrey Ferrand, Jean-Pierre Esteve, Anne B Mason, Graham S Baldwin

2009-09-01

Transferrin is the main iron transport protein found in the circulation, and the level of transferrin saturation in the blood is a..

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