The role of a liver enzyme in controlling body weight
Grant number: 566784 | Funding period: 2009 - 2011
We have shown that fructose-1,6-bisphosphatase (FBPase), an enzyme important in producing sugar from the liver and one that is connected to Type 2 diabetes, does not cause an increase in sugar production when there is more of the enzyme in mouse livers. It does, however, lower both body weight and the amount of food the mice consume. We therefore hypothesise that liver FBPase is important in controlling body weight in humans and our project aims to find out exactly how and why this happens.
Related publications (2)
The Role of Liver Fructose-1,6-Bisphosphatase in Regulating Appetite and Adiposity
Sherley Visinoni, Nurul Fathiah Izzati Khalid, Christos N Joannides, Arthur Shulkes, Mildred Yim, Jon Whitehead, Tony Tiganis, Benjamin J Lamont, Jenny M Favaloro, Joseph Proietto, Sofianos Andrikopoulos, Barbara C Fam
Liver fructose-1,6-bisphosphatase (FBPase) is a regulatory enzyme in gluconeogenesis that is elevated by obesity and dietary fat i..