Molecules involved in gut development and bowel cancer

Grant number: 566679 | Funding period: 2009 - 2011

Completed

Abstract

Wnt proteins are a family of signaling molecules that are critical for the function of normal and cancerous epithelial cells in the gut. However, the cell surface receptor that transmits Wnt signals is not known. Our research strongly implicates one Wnt receptor (FZD7). Here we test this using innovative mouse and cell line models. We wish to understand how Wnt-driven processes are activated. This knowledge will lead to novel avenues to block aberrant activation of Wnt signalling in cancer cells

Related publications (12)

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Wnt Signaling in Cancer: Not a Binary ON:OFF Switch

Dustin J Flanagan, Elizabeth Vincan, Toby J Phesse

2019-12-01

In the March 1 issue of Cancer Research, we identified the Wnt receptor Fzd7 as an attractive therapeutic target for the treatment..

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The Function of Lgr5( ) Cells in the Gastric Antrum Does Not Require Fzd7 or Myc In Vivo

Dustin Flanagan, Nick Barker, Matthias Ernst, Elizabeth Vincan, Toby Phesse

2019-09-01

The extreme chemical and mechanical forces endured by the gastrointestinal tract drive a constant renewal of the epithelial lining..

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HBV-related hepatocarcinogenesis: the role of signalling pathways and innovative ex vivo research models

Joseph Torresi, Manh Tran Bang, Dale Christiansen, Linda Earnest-Silveira, Renate Hilda Marianne Schwab, Elizabeth Vincan

2019-07-18

BACKGROUND: Hepatitis B virus (HBV) is the leading cause of liver cancer, but the mechanisms by which HBV causes liver cancer are ..

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Frizzled-7 Is Required for Wnt Signaling in Gastric Tumors with and Without Apc Mutations

Dustin J Flanagan, Nick Barker, Natasha S Di Costanzo, Elizabeth A Mason, Austin Gurney, Valerie S Meniel, Sarah Koushyar, Chloe R Austin, Matthias Ernst, Helen B Pearson, Alex Boussioutas, Hans Clevers, Toby J Phesse, Elizabeth Vincan

2019-03-01

A subset of patients with gastric cancer have mutations in genes that participate in or regulate Wnt signaling at the level of lig..

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Wnt Signalling in Gastrointestinal Epithelial Stem Cells

Dustin J Flanagan, Chloe R Austin, Elizabeth Vincan, Toby J Phesse

2018-04-01

Wnt signalling regulates several cellular functions including proliferation, differentiation, apoptosis and migration, and is crit..

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Wnt is necessary for mesenchymal to epithelial transition in colorectal cancer cells

Renate HM Schwab, Nancy Amin, Dustin J Flanagan, Timothy M Johanson, Toby J Phesse, Elizabeth Vincan

2018-03-01

BACKGROUND: Metastasis underlies most colorectal cancer mortality. Cancer cells spread through the body as single cells or small c..

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Winding back Wnt signalling: potential therapeutic targets for treating gastric cancers

Dustin J Flanagan, Elizabeth Vincan, Toby J Phesse

2017-12-01

Gastric cancer persists as a frequent and deadly disease that claims over 700 000 lives annually. Gastric cancer is a multifactori..

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Loss of the Wnt receptor frizzled 7 in the mouse gastric epithelium is deleterious and triggers rapid repopulation in vivo

Dustin J Flanagan, Nick Barker, Cameron Nowell, Hans Clevers, Matthias Ernst, Toby J Phesse, Elizabeth Vincan

2017-08-01

The gastric epithelium consists of tubular glandular units, each containing several differentiated cell types, and populations of ..

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Frizzled7: A Promising Achilles' Heel for Targeting the Wnt Receptor Complex to Treat Cancer

Toby Phesse, Dustin Flanagan, Elizabeth Vincan

2016-05-01

Frizzled7 is arguably the most studied member of the Frizzled family, which are the cognate Wnt receptors. Frizzled7 is highly con..

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Frizzled7 Functions as a Wnt Receptor in Intestinal Epithelial Lgr5( ) Stem Cells

Dustin J Flanagan, Toby J Phesse, Nick Barker, Renate HM Schwab, Nancy Amin, Jordane Malaterre, Daniel E Stange, Cameron J Nowell, Scott A Currie, Jarel TS Saw, Eva Beuchert, Robert G Ramsay, Owen J Sansom, Matthias Ernst, Hans Clevers, Elizabeth Vincan

2015-05-12

The mammalian adult small intestinal epithelium is a rapidly self-renewing tissue that is maintained by a pool of cycling stem cel..

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Partial inhibition of gp130-Jak-Stat3 signaling prevents Wnt-beta-catenin-mediated intestinal tumor growth and regeneration

Toby J Phesse, Michael Buchert, Emma Stuart, Dustin J Flanagan, Maree Faux, Shoukat Afshar-Sterle, Francesca Walker, Hui-Hua Zhang, Cameron J Nowell, Robert Jorissen, Chin Wee Tan, Yumiko Hirokawa, Moritz F Eissmann, Ashleigh R Poh, Jordane Malaterre, Helen B Pearson, David G Kirsch, Paolo Provero, Valeria Poli, Robert G Ramsay

2014-09-30

Most colon cancers arise from somatic mutations in the tumor suppressor gene APC (adenomatous polyposis coli), and these mutations..

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Wnt Signaling Regulation of Tissue Architecture (EMT and MET) and Morphogenesis: Consequences for Colorectal and Liver Cancer

Theodora Fifis, Bang M Tran, Renate HM Schwab, Timothy M Johanson, Nadia Warner, Nick Barker, Elizabeth Vincan

2014-01-01

The different branches of the Wnt signaling pathway were first characterized in developmental contexts, but in recent times, each ..

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