Understanding how pathogens infect their hosts and cause disease.
Grant number: 566926 | Funding period: 2009 - 2012
Fungi which infect humans are a major health problem, especially for those with compromised immune systems (eg. AIDS, transplant and cancer patients). These fungi cause disease by evading the immune system whilst deriving nutrients for growth. Some fungi evade the immune system by residing within host cells; a hostile and nutrient poor environment. This project will study a pathway that we have shown is required for growth inside host cells. This knowledge will open new avenues for treatment.
Related publications (2)
The pbrB Gene Encodes a Laccase Required for DHN-Melanin Synthesis in Conidia of Talaromyces (Penicillium) marneffei
Ariya Sapmak, Kylie J Boyce, Alex Andrianopoulos, Nongnuch Vanittanakom
Talaromyces marneffei (Basionym: Penicillium marneffei) is a significant opportunistic fungal pathogen in patients infected with h..
Intracellular Growth Is Dependent on Tyrosine Catabolism in the Dimorphic Fungal Pathogen Penicillium marneffei
Kylie J Boyce, Alisha McLauchlan, Lena Schreider, Alex Andrianopoulos
During infection, pathogens must utilise the available nutrient sources in order to grow while simultaneously evading or toleratin..