Studying the 'two hit' hypothesis of psychiatric illness
Grant number: 566879 | Funding period: 2009 - 2012
Early environmental factors may play an important role in the development of psychiatric illnesses, such as schizophrenia and depression. We will study an animal model which combines early developmental stress followed by treatment with a stress hormone or chronic cannabis use in adolescence. We will assess behavioural changes and the role of a growth factor in the brain, BDNF. This wil lead to a better understanding of the role of neurodevelopmental stress in psychiatric disease.
Related publications (8)
Sex-Specific Disruptions in Spatial Memory and Anhedonia in a "Two Hit" Rat Model Correspond With Alterations in Hippocampal Brain-Derived Neurotrophic Factor Expression and Signaling
Rachel A Hill, Maren Klug, Szerenke Kiss Von Soly, Michele D Binder, Anthony J Hannan, Maarten van den Buuse