The Role of Carbohydrates in Transplantation
Grant number: 566722 | Funding period: 2009 - 2011
Xenotransplantation, the transplanting of organs from other species, is now seen as a viable solution to the problem of lack of supply of suitable human donors. The recent production of genetically engineered pigs represented a critical step towards clinical xenotransplantation. However, other sugars still remain that cause rejection. This project examines the consequences of these sugars.
Related publications (3)
Structural glycobiology of antibody recognition in xenotransplantation and cancer immunotherapy
M Agostino, W Farrugia, MS Sandrin, AM Scott, E Yuriev, PA Ramsland
Carbohydrate antigens recognized by natural or preformed and elicited antibodies are central to transplantation/transfusion reject..
In silico analysis of antibody-carbohydrate interactions and its application to xenoreactive antibodies
Mark Agostino, Mauro S Sandrin, Philip E Thompson, Elizabeth Yuriev, Paul A Ramsland
Antibody-carbohydrate interactions play central roles in stimulating adverse immune reactions. The most familiar example of such a..