New Treatments for Cancer

Grant number: 566776 | Funding period: 2009 - 2011

Completed

Abstract

The enzyme system that enables us to dissolve blood clots is similar to the system that enables cancer cells to escape from the primary tumour and travel in the blood to another organ to form a secondary cancer growth. We have new results showing that some drug candidates can distinguish between these two closely related enzyme systems. We are now working to develop inhibitors that will stop cancer cells from spreading without compromising the ability to dissolve blood clots.

Related publications (3)

R2D 2 for C 4Eo: An 'alliance' of PGD 2 receptors is required for LTC 4 production by human eosinophils

GA MacKay, AG Stewart

2011-04-01

Eosinophils play important roles in limiting parasitic infection and in allergic inflammation in the asthmatic airways. Activation..

In vitro and in vivo evidence for anti-inflammatory properties of 2-methoxyestradiol

FHW Shand, SY Langenbach, CR Keenan, SP Ma, BJ Wheaton, MJ Schuliga, J Ziogas, A Stewart

2011-03-01

2-Methoxyestradiol (2MEO) is an endogenous metabolite of 17β-estradiol that interacts with estrogen receptors and microtubules. It..

Annexin-1 signals mitogen-stimulated breast tumor cell proliferation by activation of the formyl peptide receptors (FPRs) 1 and 2

T Khau, SY Langenbach, M Schuliga, T Harris, CN Johnstone, RL Anderson, AG Stewart

2011-01-01

The role of the calcium- and phospho-lipid-binding protein annexin I (ANXA1) in cell cycle regulation has been investigated in est..

University of Melbourne Researchers

Alastair Stewart