Targets for Treatment of Digestive Disorders

Grant number: 566696 | Funding period: 2009 - 2011

Completed

Abstract

Disorders of intestinal movement (motility) are common and cause considerable suffering, absenteeism and social disruption. Disorders include motility disturbances that occur in irritable bowel syndrome (IBS); constipation, which is a considerable problem in the aged; slow transit disorders; and diarrhoea. The movements of the intestine are controlled by the enteric nervous system. This project aims to find targets for therapy of motility disorders within the enteric nervous system

Related publications (4)

Transient expression of the calcitonin receptor by enteric neurons of the embryonic and early post-natal mouse

PJ Wookey, K Turner, JB Furness

2012-02-01

Calcitonin receptor-immunoreactivity (CTR-ir) was found in enteric neurons of the mouse gastrointestinal tract from embryonic day ..

Identification of endocrine cells of the stomach that express acid-sensitive background potassium (K2P9.1/TASK3) channels

K Needham, L Pontell, B Hunne, M Thacker, D McHugh, JB Furness

2010-12-01

The family of two-pore domain potassium (K<inf>2P</inf>) channels is important in setting and controlling the background potassium..

Identification of subunits of voltage-gated calcium channels and actions of pregabalin on intrinsic primary afferent neurons in the guinea-pig ileum

K Needham, R Bron, B Hunne, TV Nguyen, K Turner, M Nash, JB Furness

2010-10-01

Background The intrinsic primary afferent neurons (IPANs) in the intestine are the first neurons of intrinsic reflexes. Action pot..

The participation of the sympathetic innervation of the gastrointestinal tract in disease states

AE Lomax, KA Sharkey, JB Furness

2010-01-01

Knowledge of neural circuits, neurotransmitters and receptors involved in the sympathetic regulation of gastrointestinal (GI) func..

University of Melbourne Researchers

John Furness