Novel Metabolic Enzyme In Leishmania Parasites

Grant number: 566644 | Funding period: 2009 - 2011

Completed

Abstract

Leishmania are parasitic protozoa that cause devastating diseases in humans. This proposal will identify the enzymes involved in the biosynthesis of an unusual carbohydrate reserve material that accumulates in pathogenic stages of these parasites. Information on the structure and mode of action of these enzymes will be used to develop novel drugs that will be tested for anti-parasite activity.