Vasopressin and heart failure
Grant number: 566947 | Funding period: 2009 - 2012
Heart failure (HF) is the most common cause of hospital admission in those over 65y, and has significant morbidity and mortality. We need to develop new strategies to treat HF. Plasma vasopressin (AVP) levels are elevated in HF, and may contribute to adverse outcomes. This proposal will assess the utility of blocking the vasopressin V1 and V2 receptors in a rat model of HF. We shall also measure AVP in humans with HF. The results of this work may result in new approaches to treat HF patients.
Related publications (2)
Effects of Renal Denervation on Regional Hemodynamics and Kidney Function in Experimental Hyperdynamic Sepsis
Paolo Calzavacca, Michael Bailey, Elena Velkoska, Louise M Burrell, Rohit Ramchandra, Rinaldo Bellomo, Clive N May
OBJECTIVE: To determine the influence of the renal sympathetic nerves on the pathogenesis of septic acute kidney injury. DESIGN: I..
Postprandial effects of a high salt meal on serum sodium, arterial stiffness, markers of nitric oxide production and markers of endothelial function
Kacie M Dickinson, Peter M Clifton, Louise M Burrell, P Hugh R Barrett, Jennifer B Keogh
AIM: The aim of the study was to determine if a high salt meal containing 65 mmol Na causes a rise in sodium concentrations and a ..