Gamma-Secretase And Alzheimer Amyloid Production

Abstract

Alzheimer's disease is a devastating illness of the aged population and represents a major socio-economic problem in Australia. There is no cure or effective treatment for the illness. A toxic protein fragment known as Abeta amyloid accumulates in the brain of the diseased patients. This is produced by an enzyme called gamma-secretase. This project will investigate different forms of gamma-secretase to gain information useful for developing Alzheimer-specific drugs with little side-effects.

Related publications (1)

BACE Inhibition as a Therapeutic Strategy for Alzheimer`s Disease

Genevieve Evin, Stephanie J. Fuller, Jenny M. Gunnersen

2015-05-30