Inflammation & neuronal regulation of gastrointestinal functions
Grant number: 566502 | Funding period: 2009 - 2011
Gastrointestinal inflammation causes changes in neurons that control gut functions (motility and secretion). These changes in neuronal properties lead to the development of post-inflammatory motility disorders. This will be the first detailed study of neuronal ion channels that are changed after inflammation in the gut. Our study will open the way to the development of therapeutic agents to treat post-inflammatory IBS and other conditions that involve disorders of motility.
Related publications (1)
Morphological and functional changes in guinea-pig neurons projecting to the ileal mucosa at early stages after inflammatory damage.
Kulmira Nurgali, Zhengdong Qu, Billie Hunne, Michelle Thacker, Louise Pontell, John B Furness
In the present study the relationship between tissue damage and changed electro-physiological properties of Dogiel type II myenter..