Understanding cell orientation in development and cancer

Grant number: 566607 | Funding period: 2009 - 2012

Completed

Abstract

Cell polarity is the property of cells to be spatially oriented in a tissue or organ. We have now shown that the gene Scribble, a key regulator of cell orientation, may keep tumour development in check. In this proposal, we will examine how disruption of Scribble and associated molecules affects normal development and promotes cancer using a combination of tissue culture studies and a newly established mouse model. These studies may provide novel targets for therapeutic intervention in cancer.

Related publications (5)

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The Polarity Protein Scribble Regulates Myelination and Remyelination in the Central Nervous System

Andrew A Jarjour, Amanda Boyd, Lukas E Dow, Rebecca K Holloway, Sandra Goebbels, Patrick O Humbert, Anna Williams, Charles Ffrench-Constant

2015-03-01

The development and regeneration of myelin by oligodendrocytes, the myelin-forming cells of the central nervous system (CNS), requ..

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Scribble regulates an EMT polarity pathway through modulation of MAPK-ERK signaling to mediate junction formation

Imogen A Elsum, Claire Martin, Patrick O Humbert

2013-09-01

The crucial role the Crumbs and Par polarity complexes play in tight junction integrity has long been established, however very fe..

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Increasing Intracellular Bioavailable Copper Selectively Targets Prostate Cancer Cells

Michael A Cater, Helen B Pearson, Kamil Wolyniec, Paul Klaver, Maree Bilandzic, Brett M Paterson, Ashley I Bush, Patrick O Humbert, Sharon La Fontaine, Paul S Donnelly, Ygal Haupt

2013-07-01

The therapeutic efficacy of two bis(thiosemicarbazonato) copper complexes, glyoxalbis[N4-methylthiosemicarbazonato]Cu(II) [Cu(II)(..

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An in vivo large-scale chemical screening platform using Drosophila for anti-cancer drug discovery

Lee F Willoughby, Tanja Schlosser, Samuel A Manning, John P Parisot, Ian P Street, Helena E Richardson, Patrick O Humbert, Anthony M Brumby

2013-03-01

Anti-cancer drug development involves enormous expenditure and risk. For rapid and economical identification of novel, bioavailabl..

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Characterization of In Vivo Dlg1 Deletion on T Cell Development and Function

Lisa A Humphries, Meredith H Shaffer, Faruk Sacirbegovic, Tamar Tomassian, Kerrie-Ann McMahon, Patrick O Humbert, Oscar Silva, June L Round, Kogo Takamiya, Richard L Huganir, Janis K Burkhardt, Sarah M Russell, M Carrie Miceli

2012-09-18

BACKGROUND: The polarized reorganization of the T cell membrane and intracellular signaling molecules in response to T cell recept..

University of Melbourne Researchers