Understanding cell orientation in development and cancer

Grant number: 566607 | Funding period: 2009 - 2012

Completed

Abstract

Cell polarity is the property of cells to be spatially oriented in a tissue or organ. We have now shown that the gene Scribble, a key regulator of cell orientation, may keep tumour development in check. In this proposal, we will examine how disruption of Scribble and associated molecules affects normal development and promotes cancer using a combination of tissue culture studies and a newly established mouse model. These studies may provide novel targets for therapeutic intervention in cancer.

Related publications (5)

University of Melbourne Researchers