Understanding cell orientation in development and cancer
Grant number: 566607 | Funding period: 2009 - 2012
Cell polarity is the property of cells to be spatially oriented in a tissue or organ. We have now shown that the gene Scribble, a key regulator of cell orientation, may keep tumour development in check. In this proposal, we will examine how disruption of Scribble and associated molecules affects normal development and promotes cancer using a combination of tissue culture studies and a newly established mouse model. These studies may provide novel targets for therapeutic intervention in cancer.
Related publications (5)
The Polarity Protein Scribble Regulates Myelination and Remyelination in the Central Nervous System
Andrew A Jarjour, Amanda Boyd, Lukas E Dow, Rebecca K Holloway, Sandra Goebbels, Patrick O Humbert, Anna Williams, Charles Ffrench-Constant
The development and regeneration of myelin by oligodendrocytes, the myelin-forming cells of the central nervous system (CNS), requ..
Scribble regulates an EMT polarity pathway through modulation of MAPK-ERK signaling to mediate junction formation
Imogen A Elsum, Claire Martin, Patrick O Humbert
The crucial role the Crumbs and Par polarity complexes play in tight junction integrity has long been established, however very fe..
Increasing Intracellular Bioavailable Copper Selectively Targets Prostate Cancer Cells
Michael A Cater, Helen B Pearson, Kamil Wolyniec, Paul Klaver, Maree Bilandzic, Brett M Paterson, Ashley I Bush, Patrick O Humbert, Sharon La Fontaine, Paul S Donnelly, Ygal Haupt
The therapeutic efficacy of two bis(thiosemicarbazonato) copper complexes, glyoxalbis[N4-methylthiosemicarbazonato]Cu(II) [Cu(II)(..
An in vivo large-scale chemical screening platform using Drosophila for anti-cancer drug discovery
Lee F Willoughby, Tanja Schlosser, Samuel A Manning, John P Parisot, Ian P Street, Helena E Richardson, Patrick O Humbert, Anthony M Brumby
Anti-cancer drug development involves enormous expenditure and risk. For rapid and economical identification of novel, bioavailabl..
Characterization of In Vivo Dlg1 Deletion on T Cell Development and Function
Lisa A Humphries, Meredith H Shaffer, Faruk Sacirbegovic, Tamar Tomassian, Kerrie-Ann McMahon, Patrick O Humbert, Oscar Silva, June L Round, Kogo Takamiya, Richard L Huganir, Janis K Burkhardt, Sarah M Russell, M Carrie Miceli
BACKGROUND: The polarized reorganization of the T cell membrane and intracellular signaling molecules in response to T cell recept..