Pigment Epithelium-Derived Factor (PEDF) - How Can This Protein Be Used to Treat Bone Cancer?

Abstract

Cancer results from a sequence of alterations to genes which lead to abnormal cells dividing without control. Osteosarcoma is a cancer involving bone and can rapidly spread to surrounding and distant tissues. A number of mediators have been identified as being able to provide some regulation of this abnormal cell division. Pigment epithelium-derived factor is one such protein and further understanding of how it achieves this could be used for the development of targeted osteosarcoma treatment.