UNDERSTANDING AND CONTROLLING INFLUENZA
Grant number: 567122 | Funding period: 2010 - 2014
While current influenza vaccines blunt winter epidemics, they must be updated frequently to keep up with virus mutation and they do not protect against pandemics caused by new flu viruses (such as bird flu). This program will define how flu virus interacts with the immune system to generate immunity mediated particularly by “killer” T cells. We will use this knowledge to develop and evaluate vaccines that induce long-lasting T-cell immunity that can protect against both seasonal and pandemic flu.
Related publications (8)
Inactivated Influenza Vaccine That Provides Rapid, Innate-Immune-System-Mediated Protection and Subsequent Long-Term Adaptive Immunity
Brendon Y Chua, Chinn Yi Wong, Edin J Mifsud, Kathryn M Edenborough, Toshiki Sekiya, Amabel CL Tan, Francesca Mercuri, Steve Rockman, Weisan Chen, Stephen J Turner, Peter C Doherty, Anne Kelso, Lorena E Brown, David C Jackson
UNLABELLED: The continual threat to global health posed by influenza has led to increased efforts to improve the effectiveness of ..
Different Arms of the Adaptive Immune System Induced by a Combination Vaccine Work in Concert to Provide Enhanced Clearance of Influenza
Joanna CA Cobbin, Weiguang Zeng, David C Jackson, Lorena E Brown
Current split influenza virus vaccines that induce strain-specific neutralising antibodies provide some degree of protection again..
Influenza Virus PB1 and Neuraminidase Gene Segments Can Cosegregate during Vaccine Reassortment Driven by Interactions in the PB1 Coding Region
Joanna CA Cobbin, Chi Ong, Erin Verity, Brad P Gilbertson, Steven P Rockman, Lorena E Brown
UNLABELLED: Egg-grown influenza vaccine yields are maximized by infection with a seed virus produced by "classical reassortment" o..
Early hypercytokinemia is associated with interferon-induced transmembrane protein-3 dysfunction and predictive of fatal H7N9 infection
Zhongfang Wang, Anli Zhang, Yanmin Wan, Xinian Liu, Chao Qiu, Xiuhong Xi, Yanqin Ren, Jing Wang, Yuan Dong, Meijuan Bao, Liangzhu Li, Mingzhe Zhou, Songhua Yuan, Jun Sun, Zhaoqin Zhu, Liang Chen, Qingsheng Li, Zhiyong Zhang, Xiaoyan Zhang, Shuihua Lu
A unique avian-origin A/H7N9 influenza virus has so far caused 134 cases with 44 deaths. Probing the host factors contributing to ..
Neuraminidase-Inhibiting Antibody Is a Correlate of Cross-Protection against Lethal H5N1 Influenza Virus in Ferrets Immunized with Seasonal Influenza Vaccine
Steven Rockman, Lorena E Brown, Ian G Barr, Brad Gilbertson, Sue Lowther, Anatoly Kachurin, Olga Kachurina, Jessica Klippel, Jesse Bodle, Martin Pearse, Deborah Middleton
In preparing for the threat of a pandemic of avian H5N1 influenza virus, we need to consider the significant delay (4 to 6 months)..
A Mouse Model for the Study of Contact-Dependent Transmission of Influenza A Virus and the Factors That Govern Transmissibility
Kathryn M Edenborough, Brad P Gilbertson, Lorena E Brown
Influenza A virus transmission by direct contact is not well characterized. Here, we describe a mouse model for investigation of f..