Chemical Aided Phospoproteome Sequencing With Mass Spectrometry

Grant number: 502628 | Funding period: 2009 - 2011

Completed

Abstract

Essentially all of the body's functions from muscle contraction, energy expenditure through to appetite are controlled by a complex molecular communications system. One of the key elements involves the modification of proteins to alter their properties by adding and removing phosphate. By analysing this process in response to diet and exercise we will obtain a greater understanding of their health benefits and understand how type 2 diabetes and obesity develop at the molecular level.

Researchers