Defining the pathology of a sub-type of schizophrenia

Grant number: 566967 | Funding period: 2009 - 2011

Completed

Abstract

Schizophrenia is a group of disorders with similar symptoms and no way of distinguishing the different disorders. In our brain collection 25% of the subjects with schizophrenia have a particular chemical deficit. Screening gene expression in people with schizophrenia, with and without this deficit will give a global picture of chemical differences between the groups. Understanding the differences between sub-groups of people with schizophrenia will aid the development of better drugs for them.

Related publications (13)

Excitatory amino acid transporter (EAAT)1 and EAAT2 mRNA levels are altered in the prefrontal cortex of subjects with schizophrenia

Georgia M Parkin, Andrew Gibbons, Madhara Udawela, Brian Dean

2020-04-01

Excitatory amino acid transporter (EAAT)1 and EAAT2 mediate glutamatergic neurotransmission and prevent excitotoxicity through bin..

Associations between catechol-O-methyltransferase (COMT) genotypes at rs4818 and rs4680 and gene expression in human dorsolateral prefrontal cortex

Brian Dean, Georgia M Parkin, Andrew S Gibbons

2020-02-01

Having reported associations between catechol-O-methyltransferase (COMT) genotypes at SNPs rs4818 and rs4680 with levels of solubl..

Altered levels of dopamine transporter in the frontal pole and dorsal striatum in schizophrenia

Hirotaka Sekiguchi, Geoff Pavey, Brian Dean

2019-12-02

The dopamine hypothesis proposes that there is a hypodopaminergic state in the prefrontal cortex and a hyperdopaminergic state in ..

Changed cortical risk gene expression in major depression and shared changes in cortical gene expression between major depression and bipolar disorders

Elizabeth Scarr, Madhara Udawela, Brian Dean

2019-12-01

BACKGROUND: Mood disorders likely occur in someone with a genetic predisposition who encounters a deleterious environmental factor..

Cortical biometals: Changed levels in suicide and with mood disorders

Brian Dean, Linh Q Lam, Elizabeth Scarr, James A Duce

2019-01-15

BACKGROUND: Changes in levels of metals have been suggested to contribute to the pathophysiologies of several neurodegenerative di..

Beta-actin does not show the characteristics of a reference protein in human cortex

Georgia M Parkin, Madhara Udawela, Andrew Gibbons, Brian Dean

2019-01-01

Levels of a reference protein must be the same as a proportion of total protein in all tissues and, in the study of human diseases..

Catechol-O-methyltransferase (COMT) genotypes are associated with varying soluble, but not membrane-bound COMT protein in the human prefrontal cortex

Georgia M Parkin, Madhara Udawela, Andrew Gibbons, Elizabeth Scarr, Brian Dean

2018-12-01

Catechol-O-methyltransferase (COMT) is an enzyme that catalyses the O-methylation, and thereby the inactivation, of catechol-conta..

Changed frontal pole gene expression suggest altered interplay between neurotransmitter, developmental, and inflammatory pathways in schizophrenia

Elizabeth Scarr, Madhara Udawela, Brian Dean

2018-02-20

Schizophrenia (Sz) probably occurs after genetically susceptible individuals encounter a deleterious environmental factor that tri..

Changed gene expression in subjects with schizophrenia and low cortical muscarinic M1 receptors predicts disrupted upstream pathways interacting with that receptor

E Scarr, M Udawela, EA Thomas, B Dean

2018-02-01

We tested the hypothesis that, compared with subjects with no history of psychiatric illness (controls), changes in gene expressio..

Higher levels of different muscarinic receptors in the cortex and hippocampus from subjects with Alzheimer's disease

Elizabeth Scarr, Catriona McLean, Brian Dean

2017-03-01

It has been suggest that drugs specifically targeting muscarinic receptors will be useful in treating Alzheimer's disease. We deci..

Understanding the pathophysiology of schizophrenia: Contributions from the Melbourne Psychiatric Brain Bank

Brian Dean, David Copolov, Elizabeth Scarr

2016-11-01

The Melbourne Psychiatric Brain Bank came into existence 25years ago. This review focusses on lines of research that have used tis..

SELENBP1 expression in the prefrontal cortex of subjects with schizophrenia

M Udawela, TT Money, J Neo, MS Seo, E Scarr, B Dean, IP Everall

2015-08-04

Selenium binding protein 1 (SELENBP1) messenger RNA (mRNA) has previously been shown to be upregulated in the brain and blood from..

Muscarinic M1 receptor sequence: Preliminary studies on its effects on cognition and expression

Elizabeth Scarr, Suresh Sundram, Azita Deljo, Tiffany Francis Cowie, Andrew Stuart Gibbons, Susan Juzva, Andrew Mackinnon, Stephen J Wood, Renee Testa, Christos Pantelis, Brian Dean

2012-06-01

It has been reported that people with schizophrenia who are homozygous at the c.267C>A single nucleotide polymorphism of the choli..

University of Melbourne Researchers

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