Stress and epilepsy

Psychiatric symptoms are the strongest predictors of quality of life in patients with drug-resistant epilepsy or psychogenic nonepileptic seizures

Benjamin Johnstone, Charles B Malpas, Dennis Velakoulis, Patrick Kwan, Terence J O'Brien

2021-04-01

OBJECTIVE: This cross-sectional study aimed to determine the effect of psychiatric comorbidity and neurocognitive deficits on the ..

Ca(v)3.2 T-type calcium channel mutation influences kindling-induced thalamic neuronal firing patterns in Genetic Absence Epilepsy Rats From Strasbourg

Nihan Carcak, Idrish Ali, Kim Powell, Thomas Zheng, Filiz Onat, Terence J O'Brien

2019-07-01

OBJECTIVE: Recent data indicate that amygdala kindling leads to significant changes in interictal neuronal firing patterns of thal..

Early childhood trauma and hippocampal volumes in patients with epileptic and psychogenic seizures

Benjamin Johnstone, Dennis Velakoulis, Cheng Yi Yuan, Anthony Ang, Chris Steward, Patricia Desmond, Terence J O'Brien

2016-11-01

OBJECTIVE: Exposure to early life childhood trauma has been implicated as resulting in a vulnerability to epileptic and psychogeni..

Environmental enrichment imparts disease-modifying and transgenerational effects on genetically-determined epilepsy and anxiety

Gabi Dersi, Ezgi Ozturk, Michael R Salzberg, Margaret Morris, Terence J O'Brien, Nigel C Jones

2016-09-01

INTRODUCTION: The absence epilepsies are presumed to be caused by genetic factors, but the influence of environmental exposures on..

Reversal of evoked gamma oscillation deficits is predictive of antipsychotic activity with a unique profile for clozapine

MR Hudson, G Rind, TJ O'Brien, NC Jones

2016-04-19

Recent heuristic models of schizophrenia propose that abnormalities in the gamma frequency cerebral oscillations may be closely ti..

Environmental enrichment delays limbic epileptogenesis and restricts pathologic synaptic plasticity

Meng Yang, Ezgi Ozturk, Michael R Salzberg, Sandra Rees, Margaret Morris, Terence J O'Brien, Nigel C Jones

2016-03-01

OBJECTIVE: Environmental exposures impart powerful effects on vulnerability to many brain diseases, including epilepsy. Mesial tem..

The effect of amygdala kindling on neuronal firing patterns in the lateral thalamus in the GAERS model of absence epilepsy

Nihan Carcak, Thomas Zheng, Idrish Ali, Ahmad Abdullah, Chris French, Kim L Powell, Nigel C Jones, Leena van Raay, Gil Rind, Filiz Onat, Terence J O'Brien

2014-05-01

OBJECTIVE: The co-occurrence of absence and mesial temporal lobe epilepsy is rare in both humans and animal models. Consistent wit..

Early life maternal separation stress augmentation of limbic epileptogenesis: The role of corticosterone and HPA axis programming

Amelia S Koe, Michael R Salzberg, Margaret J Morris, Terence J O'Brien, Nigel C Jones

2014-04-01

Early life stress causes long-lasting effects on the limbic system that may be relevant to the development of mesial temporal lobe..

Chronic antidepressant treatment accelerates kindling epileptogenesis in rats

Lisa Cardamone, Michael R Salzberg, Amelia S Koe, Ezgi Ozturk, Terence J O'Brien, Nigel C Jones

2014-03-01

OBJECTIVES: Due to the high comorbidity of epilepsy and depression, antidepressant treatment is commonly indicated for patients wi..

Enduring Effects of Early Life Stress on Firing Patterns of Hippocampal and Thalamocortical Neurons in Rats: Implications for Limbic Epilepsy

Idrish Ali, Patrick O'Brien, Gaurav Kumar, Thomas Zheng, Nigel C Jones, Didier Pinault, Chris French, Margaret J Morris, Michael R Salzberg, Terence J O'Brien

2013-06-18

Early life stress results in an enduring vulnerability to kindling-induced epileptogenesis in rats, but the underlying mechanisms ..

Tissue plasminogen activator does not alter development of acquired epilepsy

Mei-Lyn Tan, Ashley Ng, Puneet S Pandher, Maithili Sashindranath, John A Hamilton, Stephen M Davis, Terence J O'Brien, Robert L Medcalf, Bernard Yan, Nigel C Jones

2012-11-01

PURPOSE:   Tissue plasminogen activator (t-PA), a proven therapy for acute ischemic stroke, is an endogenous serine protease assoc..

A genetic epilepsy rat model displays endophenotypes of psychosis

Nigel C Jones, Sally Martin, Ika Megatia, Tahir Hakami, Michael R Salzberg, Didier Pinault, Margaret J Morris, Terence J O'Brien, Maarten van den Buuse

2010-07-01

The incidence of psychosis is increased in people with epilepsy, including idiopathic generalized epilepsies. To study the biologi..

Early life stress as an influence on limbic epilepsy: an hypothesis whose time has come?

Amelia S Koe, Nigel C Jones, Michael R Salzberg

2009-01-01

The pathogenesis of mesial temporal lobe epilepsy (MTLE), the most prevalent form of refractory focal epilepsy in adults, is thoug..