Stress and epilepsy
Grant number: 566843 | Funding period: 2009 - 2011
High rates of anxiety and depression occur in individuals with temporal lobe epilepsy (TLE), the most common form of focal epilepsy in adults. Rats that have experienced early life stress show increased anxiety, decreased seizure thresholds and accelerated epilepsy as adults. We have important leads to mechanisms. The proposed study will better understand the mechanisms connecting early life stress and psychiatric disease to adult TLE, and to test interventions that may counteract these effects.
Related publications (13)
Psychiatric symptoms are the strongest predictors of quality of life in patients with drug-resistant epilepsy or psychogenic nonepileptic seizures
Benjamin Johnstone, Charles B Malpas, Dennis Velakoulis, Patrick Kwan, Terence J O'Brien
OBJECTIVE: This cross-sectional study aimed to determine the effect of psychiatric comorbidity and neurocognitive deficits on the ..
Ca(v)3.2 T-type calcium channel mutation influences kindling-induced thalamic neuronal firing patterns in Genetic Absence Epilepsy Rats From Strasbourg
Nihan Carcak, Idrish Ali, Kim Powell, Thomas Zheng, Filiz Onat, Terence J O'Brien
OBJECTIVE: Recent data indicate that amygdala kindling leads to significant changes in interictal neuronal firing patterns of thal..
Early childhood trauma and hippocampal volumes in patients with epileptic and psychogenic seizures
Benjamin Johnstone, Dennis Velakoulis, Cheng Yi Yuan, Anthony Ang, Chris Steward, Patricia Desmond, Terence J O'Brien
OBJECTIVE: Exposure to early life childhood trauma has been implicated as resulting in a vulnerability to epileptic and psychogeni..
Environmental enrichment imparts disease-modifying and transgenerational effects on genetically-determined epilepsy and anxiety
Gabi Dersi, Ezgi Ozturk, Michael R Salzberg, Margaret Morris, Terence J O'Brien, Nigel C Jones
INTRODUCTION: The absence epilepsies are presumed to be caused by genetic factors, but the influence of environmental exposures on..
Reversal of evoked gamma oscillation deficits is predictive of antipsychotic activity with a unique profile for clozapine
MR Hudson, G Rind, TJ O'Brien, NC Jones
Recent heuristic models of schizophrenia propose that abnormalities in the gamma frequency cerebral oscillations may be closely ti..
Environmental enrichment delays limbic epileptogenesis and restricts pathologic synaptic plasticity
Meng Yang, Ezgi Ozturk, Michael R Salzberg, Sandra Rees, Margaret Morris, Terence J O'Brien, Nigel C Jones
OBJECTIVE: Environmental exposures impart powerful effects on vulnerability to many brain diseases, including epilepsy. Mesial tem..
The effect of amygdala kindling on neuronal firing patterns in the lateral thalamus in the GAERS model of absence epilepsy
Nihan Carcak, Thomas Zheng, Idrish Ali, Ahmad Abdullah, Chris French, Kim L Powell, Nigel C Jones, Leena van Raay, Gil Rind, Filiz Onat, Terence J O'Brien
OBJECTIVE: The co-occurrence of absence and mesial temporal lobe epilepsy is rare in both humans and animal models. Consistent wit..
Early life maternal separation stress augmentation of limbic epileptogenesis: The role of corticosterone and HPA axis programming
Amelia S Koe, Michael R Salzberg, Margaret J Morris, Terence J O'Brien, Nigel C Jones
Early life stress causes long-lasting effects on the limbic system that may be relevant to the development of mesial temporal lobe..
Chronic antidepressant treatment accelerates kindling epileptogenesis in rats
Lisa Cardamone, Michael R Salzberg, Amelia S Koe, Ezgi Ozturk, Terence J O'Brien, Nigel C Jones
OBJECTIVES: Due to the high comorbidity of epilepsy and depression, antidepressant treatment is commonly indicated for patients wi..
Enduring Effects of Early Life Stress on Firing Patterns of Hippocampal and Thalamocortical Neurons in Rats: Implications for Limbic Epilepsy
Idrish Ali, Patrick O'Brien, Gaurav Kumar, Thomas Zheng, Nigel C Jones, Didier Pinault, Chris French, Margaret J Morris, Michael R Salzberg, Terence J O'Brien
Early life stress results in an enduring vulnerability to kindling-induced epileptogenesis in rats, but the underlying mechanisms ..
Tissue plasminogen activator does not alter development of acquired epilepsy
Mei-Lyn Tan, Ashley Ng, Puneet S Pandher, Maithili Sashindranath, John A Hamilton, Stephen M Davis, Terence J O'Brien, Robert L Medcalf, Bernard Yan, Nigel C Jones
PURPOSE: Tissue plasminogen activator (t-PA), a proven therapy for acute ischemic stroke, is an endogenous serine protease assoc..
A genetic epilepsy rat model displays endophenotypes of psychosis
Nigel C Jones, Sally Martin, Ika Megatia, Tahir Hakami, Michael R Salzberg, Didier Pinault, Margaret J Morris, Terence J O'Brien, Maarten van den Buuse
The incidence of psychosis is increased in people with epilepsy, including idiopathic generalized epilepsies. To study the biologi..