Stress and epilepsy

Grant number: 566843 | Funding period: 2009 - 2011

Completed

Abstract

High rates of anxiety and depression occur in individuals with temporal lobe epilepsy (TLE), the most common form of focal epilepsy in adults. Rats that have experienced early life stress show increased anxiety, decreased seizure thresholds and accelerated epilepsy as adults. We have important leads to mechanisms. The proposed study will better understand the mechanisms connecting early life stress and psychiatric disease to adult TLE, and to test interventions that may counteract these effects.

Related publications (12)

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Ca(v)3.2 T-type calcium channel mutation influences kindling-induced thalamic neuronal firing patterns in Genetic Absence Epilepsy Rats From Strasbourg

Nihan Carcak, Idrish Ali, Kim Powell, Thomas Zheng, Filiz Onat, Terence J O'Brien

2019-07-01

OBJECTIVE: Recent data indicate that amygdala kindling leads to significant changes in interictal neuronal firing patterns of thal..

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Early childhood trauma and hippocampal volumes in patients with epileptic and psychogenic seizures

Benjamin Johnstone, Dennis Velakoulis, Cheng Yi Yuan, Anthony Ang, Chris Steward, Patricia Desmond, Terence J O'Brien

2016-11-01

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Environmental enrichment imparts disease-modifying and transgenerational effects on genetically-determined epilepsy and anxiety

Gabi Dersi, Ezgi Ozturk, Michael R Salzberg, Margaret Morris, Terence J O'Brien, Nigel C Jones

2016-09-01

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Reversal of evoked gamma oscillation deficits is predictive of antipsychotic activity with a unique profile for clozapine

MR Hudson, G Rind, TJ O'Brien, NC Jones

2016-04-19

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Environmental enrichment delays limbic epileptogenesis and restricts pathologic synaptic plasticity

Meng Yang, Ezgi Ozturk, Michael R Salzberg, Sandra Rees, Margaret Morris, Terence J O'Brien, Nigel C Jones

2016-03-01

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The effect of amygdala kindling on neuronal firing patterns in the lateral thalamus in the GAERS model of absence epilepsy

Nihan Carcak, Thomas Zheng, Idrish Ali, Ahmad Abdullah, Chris French, Kim L Powell, Nigel C Jones, Leena van Raay, Gil Rind, Filiz Onat, Terence J O'Brien

2014-05-01

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Early life maternal separation stress augmentation of limbic epileptogenesis: The role of corticosterone and HPA axis programming

Amelia S Koe, Michael R Salzberg, Margaret J Morris, Terence J O'Brien, Nigel C Jones

2014-04-01

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Chronic antidepressant treatment accelerates kindling epileptogenesis in rats

Lisa Cardamone, Michael R Salzberg, Amelia S Koe, Ezgi Ozturk, Terence J O'Brien, Nigel C Jones

2014-03-01

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Enduring Effects of Early Life Stress on Firing Patterns of Hippocampal and Thalamocortical Neurons in Rats: Implications for Limbic Epilepsy

Idrish Ali, Patrick O'Brien, Gaurav Kumar, Thomas Zheng, Nigel C Jones, Didier Pinault, Chris French, Margaret J Morris, Michael R Salzberg, Terence J O'Brien

2013-06-18

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Tissue plasminogen activator does not alter development of acquired epilepsy

Mei-Lyn Tan, Ashley Ng, Puneet S Pandher, Maithili Sashindranath, John A Hamilton, Stephen M Davis, Terence J O'Brien, Robert L Medcalf, Bernard Yan, Nigel C Jones

2012-11-01

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A genetic epilepsy rat model displays endophenotypes of psychosis

Nigel C Jones, Sally Martin, Ika Megatia, Tahir Hakami, Michael R Salzberg, Didier Pinault, Margaret J Morris, Terence J O'Brien, Maarten van den Buuse

2010-07-01

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Early life stress as an influence on limbic epilepsy: an hypothesis whose time has come?

Amelia S Koe, Nigel C Jones, Michael R Salzberg

2009-01-01