Stress and epilepsy
Grant number: 566843 | Funding period: 2009 - 2011
High rates of anxiety and depression occur in individuals with temporal lobe epilepsy (TLE), the most common form of focal epilepsy in adults. Rats that have experienced early life stress show increased anxiety, decreased seizure thresholds and accelerated epilepsy as adults. We have important leads to mechanisms. The proposed study will better understand the mechanisms connecting early life stress and psychiatric disease to adult TLE, and to test interventions that may counteract these effects.
Related publications (12)
Ca(v)3.2 T-type calcium channel mutation influences kindling-induced thalamic neuronal firing patterns in Genetic Absence Epilepsy Rats From Strasbourg
Nihan Carcak, Idrish Ali, Kim Powell, Thomas Zheng, Filiz Onat, Terence J O'Brien
OBJECTIVE: Recent data indicate that amygdala kindling leads to significant changes in interictal neuronal firing patterns of thal..
Enduring Effects of Early Life Stress on Firing Patterns of Hippocampal and Thalamocortical Neurons in Rats: Implications for Limbic Epilepsy
Idrish Ali, Patrick O'Brien, Gaurav Kumar, Thomas Zheng, Nigel C Jones, Didier Pinault, Chris French, Margaret J Morris, Michael R Salzberg, Terence J O'Brien