tRNA synthetases as drug targets in Plasmodium falciparum
Grant number: FT0990350 | Funding period: 2010 - 2013
Malaria is a major worldwide infectious disease. The disease kills around 2 million people every year, and current drugs are increasingly failing due to parasite drug resistance, creating an urgent demand for new drugs, that inhibit different targets. The Fellow will study a new class of parasite drug targets, the transfer ribonucleic acid (tRNA) synthetase enzymes to find novel inhibitors. Compounds blocking these enzymes may lead to new drugs to combat malaria.
Related publications (18)
Aminoacyl-tRNA synthetases as drug targets in eukaryotic parasites
James S Pham, Karen L Dawson, Katherine E Jackson, Erin E Lim, Charisse Flerida A Pasaje, Kelsey EC Turner, Stuart A Ralph
Aminoacyl-tRNA synthetases are central enzymes in protein translation, providing the charged tRNAs needed for appropriate construc..
A dual-targeted aminoacyl-tRNA synthetase in Plasmodium falciparum charges cytosolic and apicoplast tRNA(Cys)
James S Pham, Reiko Sakaguchi, Lee M Yeoh, Nilushi S De Silva, Geoffrey I McFadden, Ya-Ming Hou, Stuart A Ralph
Plasmodium parasites possess two endosymbiotic organelles: a mitochondrion and a relict plastid called the apicoplast. To accommod..
An FtsH Protease Is Recruited to the Mitochondrion of Plasmodium falciparum
Aiman Tanveer, Stacey M Allen, Katherine E Jackson, Manish Charan, Stuart A Ralph, Saman Habib
The two organelles, apicoplast and mitochondrion, of the malaria parasite Plasmodium falciparum have unique morphology in liver an..
Electron tomography of Plasmodium falciparum merozoites reveals core cellular events that underpin erythrocyte invasion
Eric Hanssen, Chaitali Dekiwadia, David T Riglar, Melanie Rug, Leandro Lemgruber, Alan F Cowman, Marek Cyrklaff, Mikhail Kudryashev, Friedrich Frischknecht, Jake Baum, Stuart A Ralph
Erythrocyte invasion by merozoites forms of the malaria parasite is a key step in the establishment of human malaria disease. To d..
Recycling factors for ribosome disassembly in the apicoplast and mitochondrion of Plasmodium falciparum
Ankit Gupta, Snober S Mir, Katherine E Jackson, Erin E Lim, Priyanka Shah, Ashima Sinha, Mohammad Imran Siddiqi, Stuart A Ralph, Saman Habib
The reduced genomes of the apicoplast and mitochondrion of the malaria parasite Plasmodium falciparum are actively translated and ..
Cryo-electron tomography reveals four-membrane architecture of the Plasmodium apicoplast
Leandro Lemgruber, Mikhail Kudryashev, Chaitali Dekiwadia, David T Riglar, Jake Baum, Henning Stahlberg, Stuart A Ralph, Friedrich Frischknecht
BACKGROUND: The apicoplast is a plastid organelle derived from a secondary endosymbiosis, containing biosynthetic pathways essenti..
Determination of protein subcellular localization in apicomplexan parasites
Ben J Woodcroft, Paul J McMillan, Chaitali Dekiwadia, Leann Tilley, Stuart A Ralph
Parasites from the phylum Apicomplexa include causative agents of serious diseases including malaria (Plasmodium spp.) and toxopla..
Malaria Parasite Signal Peptide Peptidase is an ER-Resident Protease Required for Growth but not for Invasion
Danushka S Marapana, Danny W Wilson, Elizabeth S Zuccala, Chaitali D Dekiwadia, James G Beeson, Stuart A Ralph, Jake Baum
The establishment of parasite infection within the human erythrocyte is an essential stage in the development of malaria disease. ..
Subcompartmentalisation of Proteins in the Rhoptries Correlates with Ordered Events of Erythrocyte Invasion by the Blood Stage Malaria Parasite
Elizabeth S Zuccala, Alexander M Gout, Chaitali Dekiwadia, Danushka S Marapana, Fiona Angrisano, Lynne Turnbull, David T Riglar, Kelly L Rogers, Cynthia B Whitchurch, Stuart A Ralph, Terence P Speed, Jake Baum
Host cell infection by apicomplexan parasites plays an essential role in lifecycle progression for these obligate intracellular pa..
Dual targeting of aminoacyl-tRNA synthetases to the apicoplast and cytosol in Plasmodium falciparum
Katherine E Jackson, James S Pham, Michelle Kwek, Nilushi S De Silva, Stacey M Allen, Christopher D Goodman, Geoffrey I McFadden, Lluis Ribas de Pouplana, Stuart A Ralph
The causative agent of malaria, Plasmodium, possesses three translationally active compartments: the cytosol, the mitochondrion an..
Organellar proteomics reveals hundreds of novel nuclear proteins in the malaria parasite Plasmodium falciparum
Sophie C Oehring, Ben J Woodcroft, Suzette Moes, Johanna Wetzel, Olivier Dietz, Andreas Pulfer, Chaitali Dekiwadia, Pascal Maeser, Christian Flueck, Kathrin Witmer, Nicolas MB Brancucci, Igor Niederwieser, Paul Jenoe, Stuart A Ralph, Till S Voss
BACKGROUND: The post-genomic era of malaria research provided unprecedented insights into the biology of Plasmodium parasites. Due..
Protein translation in Plasmodium parasites
Katherine E Jackson, Saman Habib, Magali Frugier, Rob Hoen, Sameena Khan, James S Pham, Lluis Ribas de Pouplana, Miriam Royo, Manuel AS Santos, Amit Sharma, Stuart A Ralph
The protein translation machinery of the parasite Plasmodium is the target of important anti-malarial drugs, and encompasses many ..
Plasmodium falciparum Merozoite Invasion Is Inhibited by Antibodies that Target the PfRh2a and b Binding Domains
Tony Triglia, Lin Chen, Sash Lopaticki, Chaitali Dekiwadia, David T Riglar, Anthony N Hodder, Stuart A Ralph, Jake Baum, Alan F Cowman
Plasmodium falciparum, the causative agent of the most severe form of malaria in humans invades erythrocytes using multiple ligand..
Super-Resolution Dissection of Coordinated Events during Malaria Parasite Invasion of the Human Erythrocyte
David T Riglar, Dave Richard, Danny W Wilson, Michelle J Boyle, Chaitali Dekiwadia, Lynne Turnbull, Fiona Angrisano, Danushka S Marapana, Kelly L Rogers, Cynthia B Whitchurch, James G Beeson, Alan F Cowman, Stuart A Ralph, Jake Baum
Erythrocyte invasion by the merozoite is an obligatory stage in Plasmodium parasite infection and essential to malaria disease pro..
Isolation of viable Plasmodium falciparum merozoites to define erythrocyte invasion events and advance vaccine and drug development
Michelle J Boyle, Danny W Wilson, Jack S Richards, David T Riglar, Kevin KA Tetteh, David J Conway, Stuart A Ralph, Jake Baum, James G Beeson
During blood-stage infection by Plasmodium falciparum, merozoites invade RBCs. Currently there is limited knowledge of cellular an..
Drug target prediction and prioritization: using orthology to predict essentiality in parasite genomes
Maria A Doyle, Robin B Gasser, Ben J Woodcroft, Ross S Hall, Stuart A Ralph
BACKGROUND: New drug targets are urgently needed for parasites of socio-economic importance. Genes that are essential for parasite..