Comparison of HIV vaccines
Grant number: 628331 | Funding period: 2010 - 2012
A HIV vaccine remains elusive. Although killer T cell immunity can provide partial protection from HIV disease, we don't know the best type of killer T cells to induce by vaccination. This project compares multiple HIV vaccine strategies in macaques. We will carefully study the quality of killer T cell immunity induced using novel and cutting-edge assays. We will identify the requirements for effective killer T cell immunity to HIV.
Related publications (7)
What Lies Beneath: Antibody Dependent Natural Killer Cell Activation by Antibodies to Internal Influenza Virus Proteins
Hillary A Vanderven, Fernanda Ana-Sosa-Batiz, Sinthujan Jegaskanda, Steven Rockman, Karen Laurie, Ian Barr, Weisan Chen, Bruce Wines, P Mark Hogarth, Teresa Lambe, Sarah C Gilbert, Matthew S Parsons, Stephen J Kent
The conserved internal influenza proteins nucleoprotein (NP) and matrix 1 (M1) are well characterised for T cell immunity, but whe..
Influenza-Specific Antibody-Dependent Phagocytosis
Fernanda Ana-Sosa-Batiz, Hillary Vanderven, Sinthujan Jegaskanda, Angus Johnston, Steven Rockman, Karen Laurie, Ian Barr, Patrick Reading, Marit Lichtfuss, Stephen J Kent
BACKGROUND: Immunity to human influenza A virus (IAV) infection is only partially understood. Broadly non-neutralizing antibodies ..
Linking Pig-Tailed Macaque Major Histocompatibility Complex Class I Haplotypes and Cytotoxic T Lymphocyte Escape Mutations in Simian Immunodeficiency Virus Infection
Shayarana L Gooneratne, Hamid Alinejad-Rokny, Diako Ebrahimi, Patrick S Bohn, Roger W Wiseman, David H O'Connor, Miles P Davenport, Stephen J Kent
UNLABELLED: The influence of major histocompatibility complex class I (MHC-I) alleles on human immunodeficiency virus (HIV) divers..
Standard Trivalent Influenza Virus Protein Vaccination Does Not Prime Antibody-Dependent Cellular Cytotoxicity in Macaques
Sinthujan Jegaskanda, Thakshila H Amarasena, Karen L Laurie, Tan Hyon-Xhi, Jeff Butler, Matthew S Parsons, Sheilajen Alcantara, Janka Petravic, Miles P Davenport, Aeron C Hurt, Patrick C Reading, Stephen J Kent
Yearly vaccination with the trivalent inactivated influenza vaccine (TIV) is recommended, since current vaccines induce little cro..
Age-Associated Cross-reactive Antibody-Dependent Cellular Cytotoxicity Toward 2009 Pandemic Influenza A Virus Subtype H1N1
Sinthujan Jegaskanda, Karen L Laurie, Thakshila H Amarasena, Wendy R Winnall, Marit Kramski, Robert De Rose, Ian G Barr, Andrew G Brooks, Patrick C Reading, Stephen J Kent
BACKGROUND: During the 2009 pandemic of influenza A virus subtype H1N1 (A[H1N1]pdm09) infection, older individuals were partially ..
Trivalent Live Attenuated Influenza-Simian Immunodeficiency Virus Vaccines: Efficacy and Evolution of Cytotoxic T Lymphocyte Escape in Macaques
Jeanette C Reece, Sheilajen Alcantara, Shayarana Gooneratne, Sinthujan Jegaskanda, Thakshila Amaresena, Caroline S Fernandez, Karen Laurie, Aeron Hurt, Shelby L O'Connor, Max Harris, Janka Petravic, Alexey Martyushev, Andrew Grimm, Miles P Davenport, John Stambas, Robert De Rose, Stephen J Kent
There is an urgent need for a human immunodeficiency virus (HIV) vaccine that induces robust mucosal immunity. CD8(+) cytotoxic T ..
Cross-Reactive Influenza-Specific Antibody-Dependent Cellular Cytotoxicity Antibodies in the Absence of Neutralizing Antibodies
Sinthujan Jegaskanda, Emma R Job, Marit Kramski, Karen Laurie, Gamze Isitman, Robert de Rose, Wendy R Winnall, Ivan Stratov, Andrew G Brooks, Patrick C Reading, Stephen J Kent
A better understanding of immunity to influenza virus is needed to generate cross-protective vaccines. Engagement of Ab-dependent ..