What Is the Role of CD103+ Dendritic Cells in Infection?

Grant number: 628651 | Funding period: 2010 - 2012

Completed

Abstract

Dendritic cells are key regulators of T cell responses against pathogens. This project will examine the contribution and individual function of distinct dendritic cell to the initiation of adaptive immune responses against herpes-simplex virus. Unraveling the delicate interplay between different dendritic cells will provide novel insights into host-pathogen interactions and will have important implications for the development of efficient vaccination strategies.

Related publications (2)

Effective priming of herpes simplex virusspecific CD8 T cells in vivo does not require infected dendritic cells

PG Whitney, C Makhlouf, B MacLeod, JZ Ma, E Gressier, M Greyer, K Hochheiser, A Bachem, A Zaid, D Voehringer, WR Heath, MV Wagle, I Parish, TA Russell, SA Smith, DC Tscharke, T Gebhardt, S Bedoui

2018-02-01

Resolution of virus infections depends on the priming of virus-specific CD8+ T cells by dendritic cells (DC). While thi..

Helping themselves: Optimal virus-specific CD4 T cell responses require help via CD4 T cell licensing of dendritic cells

MR Olson, SGK Seah, J Cullen, M Greyer, K Edenborough, PC Doherty, S Bedoui, AM Lew, SJ Turner

2014-12-01

Although CD4+ T cell help (Th) is critical for inducing optimal B cell and CD8+ T cell responses, it remains..

University of Melbourne Researchers

Sammy Bedoui