Adaptation to metabolic stress

Abstract

The enzyme AMP protein kinase has three parts (subunits) and is central to controlling the body's metabolism. We have discovered that one subunit is essential for tightly associating the enzyme with muscle glycogen which is a source of high energy and efficient metabolism. We will identify where the enzyme attaches to glycogen, and how diet and exercise alter this association. Understanding this could lead to new approaches for treating Type 2 diabetes where energy metabolism is disrupted.

Related publications (2)

Attenuation of Armanni-Ebstein lesions in a rat model of diabetes by a new anti-fibrotic, anti-inflammatory agent, FT011

X Lau, Y Zhang, DJ Kelly, DI Stapleton

2013-03-01

Single fiber analyses of glycogen-related proteins reveal their differential association with glycogen in rat skeletal muscle

Robyn M Murphy, Hongyang Xu, Heidy Latchman, Noni T Larkins, Paul R Gooley, David I Stapleton

2012-12-01